Metabolic network

VK055_4330

precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit

Back to protein
Network centrality 0
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Porphyrin metabolism, no isoenzyme backup detected, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Porphyrin metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

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EC
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Pathway
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Genes
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

2.1.1.132-RXN

EC 2.1.1.132 · 2.1.1.132-RXN · not reversible · no isoenzyme backup

2 S-adenosyl-L-methionine precorrin-6B
→
precorrin-8x 2 S-adenosyl-L-homocysteine CO2 H+

RXN-13824

EC - · RXN-13824 · not reversible · no isoenzyme backup

Producing chokepoint
S-adenosyl-L-methionine precorrin-6B H+
→
precorrin-7 S-adenosyl-L-homocysteine CO2

RXN-13826

EC - · RXN-13826 · not reversible · no isoenzyme backup

Consuming chokepoint
S-adenosyl-L-methionine precorrin-7
→
precorrin-8x S-adenosyl-L-homocysteine 2 H+

Imported from KpATCC43816.sbml · 2026-07-09