Protein profile

VK055_4792

smr domain protein

Genome: KpATCC43816

Gene: AIK83319.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT73
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Amino acids 183
Annotations 5
Features 13
PDB binders 0
Druggability 0.211

Overview

Basic information about this protein and its source genome.

Accession
VK055_4792
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83319.1
Status
annotated
Amino acids
183
Structure source
AlphaFold + ColabFold
EC
3.1.-.-
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843 Binding to a ribosomal RNA. GO:0072344 A process of cytosolic translational elongation that takes place when a cytosolic ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.286
DEG E-value
1.57e-55
Localization
Cytoplasmic
ColabFold pLDDT
90.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.211
Structure A0A0H3GT73
Pocket Pocket 5
P2Rank 0.021
Structure A0A0H3GT73
Pocket Pocket 1
ColabFold model
FPocket 0.254 · Pocket 10
P2Rank 0.022 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 144 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0072344 A process of cytosolic translational elongation that takes place when a cytosolic ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 178 PANTHER PTHR35562 DNA ENDONUCLEASE SMRA-RELATED
49 176 Gene3D G3DSA:3.30.1370.110 -
49 176 InterPro IPR036063 Smr domain superfamily
98 173 ProSiteProfiles PS50828 Smr domain profile.
98 173 InterPro IPR002625 Smr domain
95 173 SMART SM00463 SMR_2
95 173 InterPro IPR002625 Smr domain
98 172 Pfam PF01713 Smr domain
98 172 InterPro IPR002625 Smr domain
96 150 SUPERFAMILY SSF160443 SMR domain-like
96 150 InterPro IPR036063 Smr domain superfamily
1 174 Hamap MF_01042 UPF0115 protein YfcN [yfcN].
1 174 InterPro IPR022990 Uncharacterised protein family UPF0115

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT73
AlphaFold — — full sequence — Viewing
ColabFold VK055_4792
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.211