Protein profile

KP13_02987

putative oxaloacetate decarboxylase gamma chain

Genome: KpKP13

Gene: oadG AHE42444.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI20
Export view
Amino acids 83
Annotations 7
Features 10
PDB binders 0
Druggability 0.317

Overview

Basic information about this protein and its source genome.

Accession
KP13_02987
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
oadG AHE42444.1
Status
annotated
Amino acids
83
Structure source
AlphaFold + ColabFold
EC
7.2.4.2
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015081 Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. GO:0036376 The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015451 Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. GO:0008948 Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
74.074
DEG E-value
8.04e-31
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.317
Structure A0A0H3GI20
Pocket Pocket 2
P2Rank
Structure A0A0H3GI20
Pocket No pockets
ColabFold model
FPocket 0.453 · Pocket 2
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015081 Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.
  • GO:0036376 The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015451 Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
  • GO:0008948 Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
34 83 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 81 NCBIfam TIGR01195 sodium pump decarboxylases, gamma subunit
4 81 InterPro IPR005899 Sodium ion-translocating decarboxylase
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 83 Hamap MF_00404 Probable oxaloacetate decarboxylase gamma chain [oadG].
1 83 InterPro IPR023424 Oxaloacetate decarboxylase, gamma chain
11 33 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 79 Pfam PF04277 Oxaloacetate decarboxylase, gamma chain
10 79 InterPro IPR005899 Sodium ion-translocating decarboxylase
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI20
AlphaFold — — full sequence — Viewing
ColabFold KP13_02987
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.317