Protein profile

KP13_02848

PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK

Genome: KpKP13

Gene: AHE42583.1 dhaK Structure source: AlphaFold + ColabFold UniProt A0A0H3GTI3
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Amino acids 356
Annotations 6
Features 12
PDB binders 1
Druggability 0.727

Overview

Basic information about this protein and its source genome.

Accession
KP13_02848
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42583.1 dhaK
Status
annotated
Amino acids
356
Structure source
AlphaFold + ColabFold
EC
2.7.1.121
GO
GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047324 Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate. GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
48.125
Human E-value
2.19e-36
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.727
Structure A0A0H3GTI3
Pocket Pocket 1
P2Rank 0.201
Structure A0A0H3GTI3
Pocket Pocket 1
ColabFold model
FPocket 0.606 · Pocket 2
P2Rank 0.159 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.
  • GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0047324 Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate.
  • GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 352 PANTHER PTHR28629 TRIOKINASE/FMN CYCLASE
12 182 FunFam G3DSA:3.40.50.10440:FF:000001 Dihydroxyacetone kinase, DhaK subunit
184 356 Gene3D G3DSA:3.30.1180.20 Dihydroxyacetone kinase; domain 2
7 352 ProSiteProfiles PS51481 DhaK domain profile.
7 352 InterPro IPR004006 DhaK domain
10 355 SUPERFAMILY SSF82549 DAK1/DegV-like
184 355 FunFam G3DSA:3.30.1180.20:FF:000002 Dihydroxyacetone kinase subunit DhaK
11 183 Gene3D G3DSA:3.40.50.10440 Dihydroxyacetone kinase; domain 1
17 351 Pfam PF02733 Dak1 domain
17 351 InterPro IPR004006 DhaK domain
1 352 NCBIfam TIGR02363 dihydroxyacetone kinase subunit DhaK
1 352 InterPro IPR012736 Dihydroxyacetone kinase DhaK, subunit 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTI3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02848
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.727
19 0.242

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.02 0.161
2 2.62 0.076
3 1.92 0.039
4 0.89 0.004

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2HA
3PNQ
P76015 90.1 Da LogP -1.46 TPSA 57.5 ✓ Ro5 ✓ Clean C(C(=O)CO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.