Protein profile

KP13_03749

Glucokinase

Genome: KpKP13

Gene: AHE43378.1 glk Structure source: AlphaFold + ColabFold UniProt W1DJW6
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Amino acids 277
Annotations 7
Features 11
PDB binders 0
Druggability 0.743

Overview

Basic information about this protein and its source genome.

Accession
KP13_03749
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43378.1 glk
Status
annotated
Amino acids
277
Structure source
AlphaFold + ColabFold
EC
2.7.1.2
GO
GO:0004340 Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005536 Binding to D-enantiomers of glucose. GO:0051156 The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. GO:0006096 The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.743
Structure W1DJW6
Pocket Pocket 18
P2Rank 0.661
Structure W1DJW6
Pocket Pocket 1
ColabFold model
FPocket 0.706 · Pocket 8
P2Rank 0.711 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 116 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0004340 Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005536 Binding to D-enantiomers of glucose.
  • GO:0051156 The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
  • GO:0006096 The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 266 NCBIfam TIGR00749 glucokinase
2 266 InterPro IPR003836 Glucokinase
3 264 Gene3D G3DSA:3.30.420.40 -
56 255 Gene3D G3DSA:3.40.367.20 -
1 275 PANTHER PTHR47690 GLUCOKINASE
4 274 SUPERFAMILY SSF53067 Actin-like ATPase domain
4 274 InterPro IPR043129 ATPase, nucleotide binding domain
56 255 FunFam G3DSA:3.40.367.20:FF:000002 Glucokinase
2 271 Pfam PF02685 Glucokinase
2 271 InterPro IPR003836 Glucokinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W1DJW6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03749
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
18 0.743
3 0.512

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.45 0.508
2 2.55 0.072
3 1.16 0.009