Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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9 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.7.1.2

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EC Number: 2.7.1.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_02851 Dihydroxyacetone kinase AlphaFold + ColabFold
2.7.1.29
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +25 total
0.994 Hit 50.3% 6.54e-42
2 KP13_02008 Trifunctional NAD biosynthesis/regulator protein NadR nadR AlphaFold + ColabFold
2.7.1.22 2.7.7.1
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0000309Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + ATP + H+ = diphosphate + NAD+. +69 total
0.958 No Hit 0.0% —
3 KP13_02403 Adenylyl-sulfate kinase cysC AlphaFold + ColabFold
2.7.1.25
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000103The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. GO:0004020Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+. +14 total
0.934 Hit 52.7% 6.03e-63
4 KP13_04700 Thymidine kinase tdk AlphaFold + ColabFold
2.7.1.21
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004797Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.903 No Hit 0.0% —
5 KP13_03749 Glucokinase glk AlphaFold + ColabFold
2.7.1.2
GO:0004340Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005536Binding to D-enantiomers of glucose. +36 total
0.743 No Hit 0.0% —
6 KP13_01129 hypothetical protein AlphaFold + ColabFold
2.7.1.217
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.637 No Hit 0.0% —
7 KP13_31809 Dephospho-CoA kinase coaE AlphaFold + ColabFold
2.7.1.24
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. +14 total
0.48 Hit 45.9% 7.74e-25
8 KP13_02430 putative inorganic polyphosphate/ATP-NAD kinase ppnK AlphaFold + ColabFold
2.7.1.23
GO:0003951Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. GO:0006741The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions. GO:0019674The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. +47 total
0.431 Hit 27.6% 8.65e-19
9 KP13_01364 PEP-sugar phosphotransferase enzyme IIB subunit AlphaFold + ColabFold
2.7.1.205 2.7.1.- 2.7.1.191 +14 total
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.03 No Hit 0.0% —
Page 1 of 1 · 9 total proteins