Protein profile

KP13_04622

hypothetical protein

Genome: KpKP13

Gene: AHE44118.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR57
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Amino acids 70
Annotations 2
Features 2
PDB binders 0
Druggability 0.721

Overview

Basic information about this protein and its source genome.

Accession
KP13_04622
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44118.1
Status
annotated
Amino acids
70
Structure source
AlphaFold + ColabFold
EC
4.2.1.2
GO
GO:0004333 Catalysis of the reaction: (S)-malate = fumarate + H2O.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.721
Structure A0A0H3GR57
Pocket Pocket 1
P2Rank 0.03
Structure A0A0H3GR57
Pocket Pocket 1
ColabFold model
FPocket 0.717 · Pocket 2
P2Rank 0.013 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0004333 Catalysis of the reaction: (S)-malate = fumarate + H2O.

Sequence Features

Domain/signature hits from InterPro and related databases.

2 records
Show feature table
Start End DB Term Name
1 67 Pfam PF10965 Protein of unknown function (DUF2767)
1 67 InterPro IPR024493 Fumarase D

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR57
AlphaFold — — full sequence — Viewing
ColabFold KP13_04622
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.721