Protein profile

KP13_03494

Toxin-antitoxin system, toxin component, HigB family protein

Genome: KpKP13

Gene: AHE45870.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KHS7
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Amino acids 100
Annotations 6
Features 2
PDB binders 0
Druggability 0.298

Overview

Basic information about this protein and its source genome.

Accession
KP13_03494
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45870.1
Status
annotated
Amino acids
100
Structure source
AlphaFold + ColabFold
EC
3.1.-.-
GO
GO:0090305 OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. GO:0110001 A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.298
Structure A0A0C7KHS7
Pocket Pocket 2
P2Rank
Structure A0A0C7KHS7
Pocket No pockets
ColabFold model
FPocket 0.03 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0090305 OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
  • GO:0110001 A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

2 records
Show feature table
Start End DB Term Name
19 92 Pfam PF09907 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system
19 92 InterPro IPR018669 Toxin-antitoxin system, mRNA interferase HigB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KHS7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03494
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.298