Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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10 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 3.1.-.-

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EC Number: 3.1.-.- ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_05489 putative esterase AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.636 No Hit 0.0% —
2 KP13_02358 putative exonuclease xni xni AlphaFold + ColabFold
3.1.-.-
GO:0017108Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. GO:0048256Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. GO:0033567The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. +58 total
0.538 No Hit 0.0% —
3 KP13_03322 putative rRNA maturation factor AlphaFold + ColabFold
3.1.-.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.493 No Hit 0.0% —
4 KP13_03303 Esterase AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.402 Hit 45.1% 8.60e-15
5 KP13_32184 oligoribonuclease AlphaFold + ColabFold
3.1.-.-
GO:0003676Binding to a nucleic acid. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.317 Hit 58.7% 3.85e-12
6 KP13_00980 Ribonuclease BN rbn AlphaFold + ColabFold
3.1.-.-
GO:0042779OBSOLETE. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. GO:0016891Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. GO:0042781Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. +36 total
0.3 Hit 46.0% 3.45e-08
7 KP13_03494 Toxin-antitoxin system, toxin component, HigB family protein AlphaFold + ColabFold
3.1.-.-
GO:0090305OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. GO:0110001A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. +25 total
0.298 No Hit 0.0% —
8 KP13_04838 Very short patch repair protein vsr AlphaFold + ColabFold
3.1.-.-
GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.292 No Hit 0.0% —
9 KP13_01040 hypothetical protein AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843Binding to a ribosomal RNA. +14 total
0.211 No Hit 0.0% —
10 KP13_01394 Protein pemK pemK AlphaFold + ColabFold
3.1.-.-
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. +25 total
0.053 No Hit 0.0% —
Page 1 of 1 · 10 total proteins