Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
226 VK055_1346 hypothetical protein AlphaFold DB model + ColabFold model
2.3.1.286
GO:0036055Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. GO:0036054Catalysis of the reaction: N(6)-malonyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +47 total
No map 0.84 Hit 45.2% 1.11e-30
227 VK055_3362 DNA gyrase, B subunit gyrB AlphaFold DB model + ColabFold model
5.6.2.2
GO:0003918Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. +58 total
No map 0.793 Hit 26.4% 1.62e-30
228 VK055_1182 DNA topoisomerase I topA AlphaFold DB model + ColabFold model
5.6.2.1
GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. +36 total
No map 0.401 Hit 27.1% 4.26e-30
229 VK055_3357 tRNA modification GTPase TrmE trmE AlphaFold DB model + ColabFold model
3.6.-.-
GO:0005525Binding to GTP, guanosine triphosphate. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0005515Binding to a protein. +58 total
No map 0.378 Hit 40.7% 5.11e-30
230 VK055_4755 sodium Bile acid symporter family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.983 Hit 27.5% 7.64e-30
231 VK055_4639 cysteine desulfurase IscS iscS AlphaFold DB model + ColabFold model
2.8.1.7
GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. +47 total
Chokepoint 19 0.469 Hit 70.7% 1.30e-29
232 VK055_0991 mannose-6-phosphate isomerase, class I manA AlphaFold DB model + ColabFold model
5.3.1.8
GO:0008270Binding to a zinc ion (Zn). GO:0009298The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +25 total
Chokepoint 3 0.226 Hit 39.8% 1.47e-29
233 VK055_2229 alkaline phosphatase H phoA Experimental + ColabFold model
3.1.3.1
GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004035Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. +14 total
Mapped 18 0.23 Hit 30.4% 2.10e-29
234 VK055_4808 folyl-polyglutamate synthetase folC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. +710 total
Chokepoint 1 0.93 Hit 37.4% 2.50e-29
235 VK055_4368 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.587 Hit 38.2% 3.26e-29
236 VK055_3044 glycerol-3-phosphate O-acyltransferase plsB AlphaFold DB model + ColabFold model –
GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0008374Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. GO:0044255OBSOLETE. The chemical reactions and pathways involving lipids, as carried out by individual cells. +36 total
Mapped 2 0.794 Hit 37.6% 4.45e-29
237 VK055_0862 iron-containing alcohol dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
No map 0.903 Hit 27.2% 5.34e-29
238 VK055_3075 methionine synthase metH AlphaFold DB model + ColabFold model
2.1.1.13
GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0042558The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. GO:0046872Binding to a metal ion. +811 total
Mapped 1 0.71 Hit 57.4% 5.62e-29
239 VK055_3844 peptidase Do family protein AlphaFold DB model + ColabFold model
3.4.21.107
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +25 total
No map 0.39 Hit 41.4% 9.20e-29
240 VK055_3747 ribosomal protein S12 rpsL AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
No map 0.171 Hit 48.2% 1.22e-28
241 VK055_4403 cysN cysN AlphaFold DB model + ColabFold model
2.7.7.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
Chokepoint 2 0.257 Hit 37.1% 2.19e-28
242 VK055_4768 nucleoside transporter, NupC family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1901642The directed movement of nucleoside across a membrane. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. +47 total
No map 0.975 Hit 26.5% 2.20e-28
243 VK055_0263 ion transport family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005216Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). GO:0006811The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. +47 total
No map 0.596 Hit 37.2% 2.44e-28
244 VK055_2177 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.336 Hit 36.3% 4.03e-28
245 VK055_4445 6-phospho-beta-glucosidase gmuD gmuD2 AlphaFold DB model + ColabFold model –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 20 0.983 Hit 32.8% 4.35e-28
246 VK055_3271 lactaldehyde reductase fucO2 AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
Mapped 3 0.982 Hit 26.2% 4.60e-28
247 VK055_2692 heme ABC exporter, ATP-binding protein CcmA ccmA9 AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +14 total
No map 0.941 Hit 35.7% 6.57e-28
248 VK055_4701 phosphoribosylaminoimidazolesuccinocarboxamide synthase purC AlphaFold DB model + ColabFold model –
GO:0004639Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
Chokepoint 1 0.434 Hit 31.7% 8.26e-28
249 VK055_4458 hydrogenase 3 and formate hydrogenlyase complex,HycG subunit AlphaFold DB model + ColabFold model –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
Mapped 2 0.429 Hit 37.1% 9.65e-28
250 VK055_1513 dihydroorotate dehydrogenase pyrD AlphaFold DB model + ColabFold model
1.3.5.2
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006222The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +69 total
Chokepoint 1 0.981 Hit 47.1% 1.05e-27
Page of 204 · 5081 total proteins