Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
251 VK055_0520 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.972 0.809 No Hit 0.0% —
252 VK055_3685 4-alpha-glucanotransferase malQ AlphaFold DB model + ColabFold model
2.4.1.25
GO:0004134Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Mapped 9 0.971 0.484 No Hit 0.0% —
253 VK055_2093 adenylate kinase adk AlphaFold DB model + ColabFold model
2.7.4.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004017Catalysis of the reaction: ATP + AMP = 2 ADP. GO:0016776Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). +47 total
Chokepoint 2 0.971 0.967 Hit 58.5% 3.59e-34
254 VK055_2084 copper-translocating P-type ATPase AlphaFold DB model + ColabFold model
7.2.2.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. +1316 total
No map 0.971 0.82 Hit 41.3% 1.14e-10
255 VK055_5021 putative serotype K2 polymerase AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.970 0.983 No Hit 0.0% —
256 VK055_4601 L-aspartate oxidase nadB AlphaFold DB model + ColabFold model
1.4.3.16
GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008734Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. Can also use fumatate as electron acceptor under anaerobic conditions, yielding succinate. +36 total
Mapped 2 0.970 0.347 Hit 33.5% 1.22e-23
257 VK055_4240 triose-phosphate Transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.970 0.748 No Hit 0.0% —
258 VK055_3315 H+ antiporter-2 family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.970 0.881 No Hit 0.0% —
259 VK055_3033 qor qor AlphaFold DB model + ColabFold model
1.6.5.5
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Mapped 1 0.970 0.985 Hit 45.9% 7.48e-08
260 VK055_2719 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.970 0.828 No Hit 0.0% —
261 VK055_2246 homocysteine S-methyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0008270Binding to a zinc ion (Zn). +36 total
No map 0.970 0.461 Hit 26.4% 1.77e-13
262 VK055_2112 sigma70 sigma factor YlaC family protein AlphaFold DB model + ColabFold model – – No map N/A 0.97 No Hit 0.0% —
263 VK055_1976 &gamma-glutamyl:cysteine ligase YbdK ybdK AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0004357Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. +14 total
No map 0.970 0.225 No Hit 0.0% —
264 VK055_1933 enterochelin esterase fes AlphaFold DB model + ColabFold model –
GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005506Binding to an iron (Fe) ion. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Chokepoint 4 0.970 0.302 No Hit 0.0% —
265 VK055_1736 urocanate hydratase hutU AlphaFold DB model + ColabFold model
4.2.1.49
GO:0016153Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. +14 total
Chokepoint 1 0.970 0.831 Hit 34.6% 1.33e-92
266 VK055_1242 bacterial extracellular solute-binding family protein AlphaFold DB model + ColabFold model – – No map 0.970 0.947 No Hit 0.0% —
267 VK055_1200 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.970 0.999 Hit 22.0% 5.39e-16
268 VK055_1194 anthranilate synthase component II trpD AlphaFold DB model + ColabFold model –
GO:0004048Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.
Chokepoint 1 0.970 0.783 No Hit 0.0% —
269 VK055_0873 triose-phosphate Transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.970 0.764 No Hit 0.0% —
270 VK055_4946 aryl-phospho-beta-D-glucosidase BglH bglH AlphaFold DB model + ColabFold model –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 22 0.969 0.716 Hit 36.8% 3.19e-11
271 VK055_4708 acrD acrD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +58 total
No map 0.969 0.674 No Hit 0.0% —
272 VK055_4085 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.969 0.916 No Hit 0.0% —
273 VK055_3684 glycogen/starch/alpha-glucan phosphorylases family protein glgP2 Experimental + ColabFold model
2.4.1.1
GO:0008184Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004645Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. +47 total
No map 0.969 0.984 Hit 49.6% 1.61e-69
274 VK055_3408 lamB porin family protein AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. +58 total
No map 0.969 0.845 No Hit 0.0% —
275 VK055_3388 eamA-like transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.969 0.824 No Hit 0.0% —
Page of 204 · 5081 total proteins