Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3051 VK055_2919 translation elongation factor P efp AlphaFold + ColabFold –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0043043The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.471 No Hit 0.0% —
3052 VK055_4167 3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG ubiX AlphaFold + ColabFold
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2.
0.47 No Hit 0.0% —
3053 VK055_4639 cysteine desulfurase IscS iscS AlphaFold + ColabFold
2.8.1.7
GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. +47 total
0.469 Hit 70.7% 1.30e-29
3054 VK055_3580 endoglucanase AlphaFold + ColabFold
3.2.1.-
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008810Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. +14 total
0.469 No Hit 0.0% —
3055 VK055_1970 oligopeptide/dipeptide ABC transporter, ATP-binding, C-terminal domain protein AlphaFold + ColabFold
7.4.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
0.469 Hit 32.6% 1.33e-07
3056 VK055_0918 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.469 No Hit 0.0% —
3057 VK055_5158 bacterial regulatory, gntR family protein AlphaFold + ColabFold – – 0.468 No Hit 0.0% —
3058 VK055_5051 exonuclease I, 3' -- 5' specific deoxyribophosphodiesterase AlphaFold + ColabFold
3.1.11.1
GO:0003676Binding to a nucleic acid. GO:0004529Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. +47 total
0.468 No Hit 0.0% —
3059 VK055_3996 DNA primase dnaG AlphaFold + ColabFold
2.7.7.101
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0008270Binding to a zinc ion (Zn). GO:0006269The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer. +710 total
0.468 No Hit 0.0% —
3060 VK055_3511 glycosyl transferase 2 family protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.468 No Hit 0.0% —
3061 VK055_2069 purE purE AlphaFold + ColabFold
5.4.99.18
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0034023Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
0.468 Hit 26.4% 1.36e-07
3062 VK055_1637 putative phage protein ColabFold – – 0.468 No Hit 0.0% —
3063 VK055_1267 protein kinase yeaG AlphaFold + ColabFold
2.7.11.1
GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
0.468 No Hit 0.0% —
3064 VK055_0298 hypothetical protein ColabFold – – 0.468 No Hit 0.0% —
3065 VK055_4977 fructose bisphosphate aldolase AlphaFold + ColabFold
4.1.2.13
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.467 No Hit 0.0% —
3066 VK055_3467 fructose-1,6-bisphosphatase, class II glpX AlphaFold + ColabFold –
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0042132Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +36 total
0.467 No Hit 0.0% —
3067 VK055_2677 hypothetical protein AlphaFold + ColabFold – – 0.467 No Hit 0.0% —
3068 VK055_1497 integral membrane, YccS/YhfK family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.467 No Hit 0.0% —
3069 VK055_0052 arabinose import ATP-binding protein AraG araG AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.467 Hit 33.3% 5.01e-10
3070 VK055_4982 helix-turn-helix domain protein AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.466 No Hit 0.0% —
3071 VK055_4770 hypothetical protein AlphaFold + ColabFold – – 0.466 No Hit 0.0% —
3072 VK055_4584 hypothetical protein AlphaFold + ColabFold –
GO:0005507Binding to a copper (Cu) ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.466 Hit 36.7% 2.15e-09
3073 VK055_2981 pfkB carbohydrate kinase family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.466 Hit 22.8% 1.85e-08
3074 VK055_2749 hypothetical protein AlphaFold + ColabFold – – 0.466 No Hit 0.0% —
3075 VK055_2647 hypothetical protein ColabFold – – 0.466 No Hit 0.0% —
Page of 204 · 5081 total proteins