Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3101 VK055_3909 csdA, DEAD-box RNA helicase AlphaFold + ColabFold
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016817Catalysis of the hydrolysis of any acid anhydride. GO:0003676Binding to a nucleic acid. +912 total
0.46 Hit 50.8% 6.23e-12
3102 VK055_3905 ribosomal protein S15 rpsO AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
0.46 No Hit 0.0% —
3103 VK055_3891 phosphoglucosamine mutase glmM AlphaFold + ColabFold
5.4.2.10
GO:0008966Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. +69 total
0.46 Hit 30.6% 1.45e-08
3104 VK055_2588 phosphoserine phosphatase SerB serB AlphaFold + ColabFold
3.1.3.3
GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0036424Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.46 Hit 34.1% 3.25e-20
3105 VK055_2563 GPR1/FUN34/yaaH family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015360Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). +14 total
0.46 No Hit 0.0% —
3106 VK055_2345 4-nitrobenzaldehyde reductase (multifunctional) AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990002Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. +14 total
0.46 Hit 45.5% 2.99e-10
3107 VK055_4138 yecA family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.459 No Hit 0.0% —
3108 VK055_3616 nickel import ATP-binding protein NikE nikE3 AlphaFold + ColabFold
7.2.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015413Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
0.459 Hit 32.2% 5.41e-14
3109 VK055_3461 CDP-diacylglycerol pyrophosphatase cdh AlphaFold + ColabFold
3.6.1.26
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008715Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +25 total
0.459 No Hit 0.0% —
3110 VK055_3329 ATP synthase I chain family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.459 No Hit 0.0% —
3111 VK055_2149 hypothetical protein ColabFold – – 0.459 No Hit 0.0% —
3112 VK055_2131 bacterial regulatory, gntR family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.459 Hit 23.1% 8.10e-13
3113 VK055_2033 putative sugar kinase AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008865Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. +14 total
0.459 Hit 28.9% 4.57e-16
3114 VK055_1623 hypothetical protein AlphaFold + ColabFold – – 0.459 No Hit 0.0% —
3115 VK055_5115 hypothetical protein AlphaFold + ColabFold – – 0.458 No Hit 0.0% —
3116 VK055_4655 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispG AlphaFold + ColabFold –
GO:0046429Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0005506Binding to an iron (Fe) ion. +25 total
0.458 No Hit 0.0% —
3117 VK055_4016 glnD PII-uridylyltransferase family protein AlphaFold + ColabFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0008882Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
0.458 No Hit 0.0% —
3118 VK055_2482 UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0047480Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. +25 total
0.458 No Hit 0.0% —
3119 VK055_0153 proteasome subunit AlphaFold + ColabFold –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
0.458 No Hit 0.0% —
3120 VK055_4654 putative membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008360Any process that modulates the surface configuration of a cell. +14 total
0.457 No Hit 0.0% —
3121 VK055_3495 pantetheine-phosphate adenylyltransferase coaD Experimental + ColabFold
2.7.7.3
GO:0004595Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.457 No Hit 0.0% —
3122 VK055_2632 AAA domain family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +47 total
0.457 No Hit 0.0% —
3123 VK055_2026 periplasmic binding family protein AlphaFold + ColabFold – – 0.457 No Hit 0.0% —
3124 VK055_1971 oligopeptide/dipeptide ABC transporter, ATP-binding, C-terminal domain protein AlphaFold + ColabFold
7.4.2.10
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
0.457 Hit 38.0% 3.43e-06
3125 VK055_0406 diacetyl reductase (S-acetoin forming) budC Experimental + ColabFold
1.1.1.304
GO:0045150The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. GO:0019152Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. This reaction is catalyzed in the reverse direction. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.457 Hit 41.9% 7.64e-11
Page of 204 · 5081 total proteins