Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
876 VK055_3840 oxaloacetate decarboxylase alpha subunit oadA2 Experimental + AlphaFold DB model + ColabFold model
7.2.4.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008948Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate. +47 total
Mapped 1 0.911 0.3 Hit 42.0% 9.96e-06
877 VK055_2949 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB pgaB AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0043708The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Mapped 1 0.911 0.508 No Hit 0.0% —
878 VK055_2544 oxaloacetate decarboxylase alpha subunit oadA Experimental + AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008948Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate.
Mapped 1 0.911 0.3 Hit 42.0% 8.33e-06
879 VK055_2533 carB carB AlphaFold DB model + ColabFold model
6.3.4.16 6.3.5.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0046872Binding to a metal ion. +69 total
Chokepoint 7 0.911 0.918 Hit 44.5% 0.00e+00
880 VK055_2528 diadenosine tetraphosphatase apaH AlphaFold DB model + ColabFold model
3.6.1.41
GO:0008803Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
Mapped 1 0.911 0.609 No Hit 0.0% —
881 VK055_0852 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
Chokepoint 1 0.911 0.663 No Hit 0.0% —
882 VK055_0335 bacterial extracellular solute-binding family protein AlphaFold DB model + ColabFold model –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
No map 0.911 0.476 No Hit 0.0% —
883 VK055_4882 his Kinase A domain protein AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
No map 0.910 0.489 No Hit 0.0% —
884 VK055_4801 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.910 0.755 No Hit 0.0% —
885 VK055_3203 threonine ammonia-lyase, biosynthetic ilvA AlphaFold DB model + ColabFold model
4.3.1.19
GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0009097OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. +47 total
Chokepoint 2 0.910 0.343 Hit 51.6% 1.68e-14
886 VK055_2564 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.910 0.888 No Hit 0.0% —
887 VK055_2274 putative transcriptional regulator AlphaFold DB model + ColabFold model – – No map N/A 0.91 No Hit 0.0% —
888 VK055_1927 entS MFS transporter entS AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0042931Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. GO:0042930The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.910 0.668 No Hit 0.0% —
889 VK055_1726 excinuclease ABC subunit B uvrB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009380Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map 0.910 0.333 Hit 33.0% 6.73e-06
890 VK055_0886 lacI transcriptional repressor lacI AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.910 0.638 No Hit 0.0% —
891 VK055_5091 trbC/VIRB2 family protein AlphaFold DB model + ColabFold model – – No map N/A 0.909 No Hit 0.0% —
892 VK055_4017 bifunctional protein RfaE, domain I rfaE AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +912 total
No map 0.909 0.373 Hit 39.7% 1.44e-06
893 VK055_3733 phosphoribulokinase / Uridine kinase family protein AlphaFold DB model + ColabFold model
2.7.1.19
GO:0008974Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
No map 0.909 0.061 No Hit 0.0% —
894 VK055_3452 PTS system, glucose-like IIB component domain protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +36 total
No map 0.909 0.764 No Hit 0.0% —
895 VK055_3159 phospholipase A pldA AlphaFold DB model + ColabFold model
3.1.1.32 3.1.1.4
GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.909 0.67 No Hit 0.0% —
896 VK055_1000 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.909 0.971 No Hit 0.0% —
897 VK055_0763 resiniferatoxin-binding, phosphotriesterase-related protein AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0009056A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
No map 0.909 0.662 Hit 35.5% 3.60e-35
898 VK055_0502 tyrosine--tRNA ligase tyrS AlphaFold DB model + ColabFold model
6.1.1.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006437The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004831Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. +69 total
Chokepoint 3 0.909 0.419 Hit 42.0% 1.37e-53
899 VK055_4722 aldehyde dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008774Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
No map 0.908 0.559 Hit 24.1% 3.62e-08
900 VK055_4269 cupin 2, conserved barrel domain protein AlphaFold DB model + ColabFold model – – No map 0.908 0.16 No Hit 0.0% —
Page of 204 · 5081 total proteins