Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
901 VK055_2811 trehalose operon repressor treR AlphaFold DB model + ColabFold model –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005991The chemical reactions and pathways involving trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.908 0.612 No Hit 0.0% —
902 VK055_2224 shikimate kinase 2 aroL AlphaFold DB model + ColabFold model
2.7.1.71
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +47 total
Chokepoint 1 0.908 0.691 Hit 25.1% 6.40e-08
903 VK055_2197 queuine tRNA-ribosyltransferase tgt AlphaFold DB model + ColabFold model
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0008479Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. +47 total
Chokepoint 2 0.908 0.64 Hit 48.9% 5.60e-40
904 VK055_1406 bacterial regulatory, tetR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.908 0.186 No Hit 0.0% —
905 VK055_0788 3-oxoacyl-(Acyl-carrier-protein) reductase fabG2 Experimental + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004316Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
Chokepoint 10 0.908 0.892 Hit 43.1% 1.29e-07
906 VK055_0615 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
No map 0.908 0.618 Hit 36.1% 3.81e-13
907 VK055_5163 hypothetical protein ColabFold model – – No map N/A 0.907 No Hit 0.0% —
908 VK055_4790 fatty oxidation complex, alpha subunit FadJ fadJ AlphaFold DB model + ColabFold model –
GO:0003857Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +912 total
Mapped 5 0.907 0.698 Hit 40.9% 6.32e-06
909 VK055_4762 glutamate--tRNA ligase gltX AlphaFold DB model + ColabFold model
6.1.1.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0043039The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. GO:0006424The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +710 total
Chokepoint 2 0.907 0.394 Hit 36.4% 3.48e-65
910 VK055_3929 2-hydroxy-3-oxopropionate reductase AlphaFold DB model + ColabFold model
1.1.1.60
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. +36 total
Mapped 2 0.907 0.239 Hit 36.8% 2.04e-26
911 VK055_3657 ugpB ugpB AlphaFold DB model + ColabFold model –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.907 0.425 No Hit 0.0% —
912 VK055_3466 ferredoxin-NADP reductase fpr Experimental + ColabFold model
1.18.1.2 1.19.1.1
GO:0004324Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.907 0.943 No Hit 0.0% —
913 VK055_3031 alanine racemase alr2 AlphaFold DB model + ColabFold model
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. +47 total
Mapped 1 0.907 0.551 No Hit 0.0% —
914 VK055_3030 tyrosine aminotransferase tyrB2 AlphaFold DB model + ColabFold model
2.6.1.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +69 total
Mapped 6 0.907 0.915 Hit 41.0% 3.60e-100
915 VK055_2700 cupin superfamily protein AlphaFold DB model + ColabFold model –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
No map 0.907 0.158 No Hit 0.0% —
916 VK055_0693 oxidoreductase, Gfo/Idh/MocA family AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.907 0.671 Hit 26.4% 2.87e-07
917 VK055_0331 xylose isomerase-like TIM barrel family protein AlphaFold DB model + ColabFold model
4.2.1.118
GO:0046565Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. +14 total
No map 0.907 0.6 Hit 26.4% 2.18e-07
918 VK055_0135 flagellin N-methylase family protein AlphaFold DB model + ColabFold model – – No map 0.907 0.741 No Hit 0.0% —
919 VK055_4791 phosphohistidine phosphatase SixA sixA AlphaFold DB model + ColabFold model –
GO:0101006Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
Mapped 2 0.906 0.048 No Hit 0.0% —
920 VK055_4714 maeB AlphaFold DB model + ColabFold model –
GO:0004471Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0046872Binding to a metal ion. +36 total
Mapped 1 0.906 0.811 Hit 26.1% 2.66e-13
921 VK055_4684 polyphosphate kinase 1 ppk1 AlphaFold DB model + ColabFold model
2.7.4.1
GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0006799The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
No map 0.906 0.509 No Hit 0.0% —
922 VK055_3671 gntU gluconate Gnt transporter gntU AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.906 0.888 No Hit 0.0% —
923 VK055_3237 5,10-methylenetetrahydrofolate reductase metF AlphaFold DB model + ColabFold model
1.5.1.54
GO:0004489Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +47 total
Mapped 2 0.906 0.142 Hit 38.2% 3.52e-24
924 VK055_2777 inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase iolG AlphaFold DB model + ColabFold model
1.1.1.18
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0050112Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH. GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
Chokepoint 1 0.906 0.339 No Hit 0.0% —
925 VK055_2377 cytidylyltransferase family protein AlphaFold DB model + ColabFold model
2.7.7.41
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.906 0.737 Hit 30.6% 2.37e-10
Page of 204 · 5081 total proteins