Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
901 VK055_1741 HAD ATPase, P-type, IC family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005215Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. +1114 total
0.863 Hit 45.7% 2.21e-25
902 VK055_1707 transcriptional repressor ybiH AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.863 No Hit 0.0% —
903 VK055_3809 sodium/pantothenate symporter panF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015233Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +69 total
0.862 Hit 25.3% 4.81e-15
904 VK055_3722 amidohydrolase family protein AlphaFold + ColabFold
3.5.4.1
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. +25 total
0.862 No Hit 0.0% —
905 VK055_3181 wzyE family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.862 No Hit 0.0% —
906 VK055_1561 recombination factor ycaJ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.862 Hit 41.1% 1.73e-97
907 VK055_1328 cupin superfamily protein AlphaFold + ColabFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
0.862 Hit 37.5% 7.35e-07
908 VK055_1287 hypothetical protein AlphaFold + ColabFold – – 0.862 No Hit 0.0% —
909 VK055_0258 periplasmic oligopeptide-binding protein oppA AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
0.862 No Hit 0.0% —
910 VK055_3365 surface antigen family protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.861 No Hit 0.0% —
911 VK055_2247 amino acid permease family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.861 Hit 23.1% 2.22e-08
912 VK055_1788 cyd operon protein YbgT AlphaFold + ColabFold – – 0.861 No Hit 0.0% —
913 VK055_2580 phosphoglycerate mutase 2 ytjC AlphaFold + ColabFold
5.4.2.-
GO:0004619Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +25 total
0.86 Hit 35.9% 2.96e-14
914 VK055_1907 S-methyl-5-thioribose-1-phosphate isomerase mtnA AlphaFold + ColabFold
5.3.1.23
GO:0044249OBSOLETE. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0046523Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. +14 total
0.86 Hit 41.2% 8.83e-71
915 VK055_0586 bacterial extracellular solute-binding, 3 familyprotein AlphaFold + ColabFold – – 0.86 No Hit 0.0% —
916 VK055_0077 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase msbB AlphaFold + ColabFold
2.3.1.243
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +47 total
0.86 No Hit 0.0% —
917 VK055_2712 snoaL-like domain protein AlphaFold + ColabFold – – 0.859 No Hit 0.0% —
918 VK055_2143 pyridoxal-phosphate dependent enzyme family protein AlphaFold + ColabFold
4.4.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +25 total
0.859 Hit 23.7% 3.85e-15
919 VK055_1496 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.859 No Hit 0.0% —
920 VK055_1414 pirin family protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion.
0.859 Hit 35.7% 6.62e-44
921 VK055_0410 beta-D-hydroxybutyrate dehydrogenase bdhA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003858Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.
0.859 Hit 38.2% 4.17e-14
922 VK055_0363 bacterial extracellular solute-binding, 3 familyprotein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
0.859 Hit 34.0% 1.22e-08
923 VK055_4507 proX proX AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.858 No Hit 0.0% —
924 VK055_1607 NADPH-flavin oxidoreductase frp AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.858 No Hit 0.0% —
925 VK055_1301 3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein Experimental + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
0.858 No Hit 0.0% —
Page of 204 · 5081 total proteins