Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5080 / 5081 proteins Structure: ColabFold

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 VK055_3595 asmA family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
No map 0.99 No Hit 0.0% —
102 VK055_2129 high-affinity nickel-transport family protein AlphaFold DB model + ColabFold model –
GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +47 total
No map 0.99 No Hit 0.0% —
103 VK055_0439 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.99 No Hit 0.0% —
104 VK055_0013 outer membrane protein C ompC AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.99 No Hit 0.0% —
105 VK055_3576 cellulose synthase catalytic subunit (UDP-forming) bcsA AlphaFold DB model + ColabFold model
2.4.1.12
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016760Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1). +47 total
No map 0.989 No Hit 0.0% —
106 VK055_3537 xylH xylH AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.989 No Hit 0.0% —
107 VK055_3341 glutamine-fructose-6-phosphate transaminase glmS AlphaFold DB model + ColabFold model
2.6.1.16
GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. GO:0097367Binding to a carbohydrate derivative. GO:1901137The chemical reactions and pathways resulting in the formation of carbohydrate derivative. +710 total
Mapped 2 0.989 Hit 41.2% 3.40e-94
108 VK055_3154 alpha/beta hydrolase fold family protein AlphaFold DB model + ColabFold model
3.1.1.5
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004622Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
No map 0.989 No Hit 0.0% —
109 VK055_2715 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.989 No Hit 0.0% —
110 VK055_1805 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.989 No Hit 0.0% —
111 VK055_1455 putrescine importer puuP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.989 Hit 25.3% 1.97e-09
112 VK055_1317 bacterial regulatory, arsR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0097063Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). +47 total
No map 0.989 No Hit 0.0% —
113 VK055_1067 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.989 No Hit 0.0% —
114 VK055_0977 NAD(P) transhydrogenase beta subunit AlphaFold DB model + ColabFold model
7.1.1.1
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008750Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+. +14 total
No map 0.989 Hit 52.3% 9.01e-157
115 VK055_0568 zinc-binding dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
No map 0.989 Hit 40.8% 9.54e-07
116 VK055_0086 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.989 No Hit 0.0% —
117 VK055_4735 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.988 No Hit 0.0% —
118 VK055_3636 yhhN-like family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.988 No Hit 0.0% —
119 VK055_3147 2-OCTAPRENYL-METHOXY-BENZOQ-METH bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase ubiE AlphaFold DB model + ColabFold model
2.1.1.163 2.1.1.201
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008425Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. GO:0043770Catalysis of the reaction: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteine. Reaction substrates can have varying polyprenyl side chain length. +36 total
No map 0.988 Hit 56.0% 9.33e-11
120 VK055_2909 mechanosensitive ion channel family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.988 No Hit 0.0% —
121 VK055_2237 ABC transporter transmembrane region 2 family protein AlphaFold DB model + ColabFold model –
GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.988 No Hit 0.0% —
122 VK055_1508 integral membrane, PqiA family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.988 No Hit 0.0% —
123 VK055_1218 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.988 No Hit 0.0% —
124 VK055_0671 catalase/peroxidase HPI katG AlphaFold DB model + ColabFold model
1.11.1.21
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +58 total
Chokepoint 4 0.988 No Hit 0.0% —
125 VK055_0619 formate dehydrogenase, gamma subunit AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008863Catalysis of the reaction: formate + NAD+ = CO2 + NADH. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +811 total
Mapped 1 0.988 No Hit 0.0% —
Page of 204 · 5080 total proteins