Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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Applied filters EC Number: 3.4.16.4

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EC Number: 3.4.16.4 ×
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_03339 Penicillin-binding protein 2 mrdA AlphaFold DB model + ColabFold model
3.4.16.4
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +69 total
No map 0.724 0.315 No Hit 0.0% —
2 KP13_01582 Peptidoglycan synthase ftsI ftsI AlphaFold DB model + ColabFold model
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
No map 0.699 0.202 No Hit 0.0% —
3 KP13_00697 Penicillin-binding protein 1A mrcA AlphaFold DB model + ColabFold model
2.4.99.28 3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.566 0.568 No Hit 0.0% —
4 KP13_04583 Penicillin-binding protein 2 AlphaFold DB model + ColabFold model
3.4.16.4
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +69 total
No map 0.525 0.074 No Hit 0.0% —
5 KP13_01911 Peptidoglycan synthase ftsI Experimental + ColabFold model
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
No map 0.520 0.756 No Hit 0.0% —
6 KP13_03342 D-alanyl-D-alanine carboxypeptidase dacA dacA AlphaFold DB model + ColabFold model
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +710 total
No map 0.401 0.822 No Hit 0.0% —
7 KP13_05419 D-alanyl-D-alanine carboxypeptidase dacD dacD AlphaFold DB model + ColabFold model
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +58 total
No map 0.280 0.551 No Hit 0.0% —
8 KP13_04272 D-alanyl-D-alanine carboxypeptidase dacC dacC AlphaFold DB model + ColabFold model
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +710 total
No map 0.172 0.669 No Hit 0.0% —
Page 1 of 1 · 8 total proteins