Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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3 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 5.1.3.2

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EC Number: 5.1.3.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_02995 UDP-glucose 4-epimerase galE AlphaFold + ColabFold
5.1.3.2
GO:0003978Catalysis of the reaction: UDP-glucose = UDP-galactose. GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.706 Hit 60.4% 9.88e-99
2 KP13_00202 ADP-L-glycero-D-manno-heptose-6-epimerase hldD AlphaFold + ColabFold
5.1.3.20
GO:0008712Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.416 Hit 25.4% 4.21e-06
3 KP13_02352 L-fucose mutarotase fucU AlphaFold + ColabFold
5.1.3.29
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. GO:0016854Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. +69 total
0.415 Hit 47.2% 2.05e-36
Page 1 of 1 · 3 total proteins