Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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6 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 5.3.1.1

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EC Number: 5.3.1.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_03772 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA AlphaFold + ColabFold
5.3.1.16
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0003949Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.968 No Hit 0.0% —
2 KP13_00157 Triosephosphate isomerase tpiA AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.766 Hit 57.6% 1.74e-06
3 KP13_04888 Triosephosphate isomerase 2 tpiA2 AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +36 total
0.601 Hit 42.6% 3.15e-18
4 KP13_00592 L-rhamnose isomerase rhaA AlphaFold + ColabFold
5.3.1.14
GO:0019299OBSOLETE. The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. GO:0030145Binding to a manganese ion (Mn). GO:0008740Catalysis of the reaction: L-rhamnose = L-rhamnulose. +36 total
0.455 No Hit 0.0% —
5 KP13_02873 Uronate isomerase uxaC AlphaFold + ColabFold
5.3.1.12
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008880Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0019698The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. +14 total
0.414 No Hit 0.0% —
6 KP13_31865 Arabinose 5-phosphate isomerase GutQ gutQ AlphaFold + ColabFold
5.3.1.13
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +58 total
0.346 No Hit 0.0% —
Page 1 of 1 · 6 total proteins