Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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3 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 5.6.2.2

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EC Number: 5.6.2.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_00051 DNA gyrase subunit B gyrB AlphaFold + ColabFold
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. +58 total
0.793 Hit 26.4% 1.62e-30
2 KP13_00955 DNA gyrase subunit A gyrA AlphaFold + ColabFold
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. +811 total
0.336 Hit 27.6% 1.59e-15
3 KP13_02784 DNA topoisomerase 4 subunit A parC AlphaFold + ColabFold
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. +811 total
0.265 Hit 27.3% 2.00e-09
Page 1 of 1 · 3 total proteins