Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2626 KP13_00390 Alanine racemase, biosynthetic alr AlphaFold + ColabFold
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
No map 0.551 No Hit 0.0% —
2627 KP13_31834 aspartate racemase AlphaFold + ColabFold –
GO:0047661Catalysis of the reaction: an L-amino acid = a D-amino acid. GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. +14 total
No map 0.55 No Hit 0.0% —
2628 KP13_25184 3-carboxy-cis,cis-muconate cycloisomerase pcaB AlphaFold + ColabFold
5.5.1.2
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. +14 total
No map 0.55 Hit 30.3% 3.22e-10
2629 KP13_04894 Lipoprotein-releasing system ATP-binding protein LolD lolD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
No map 0.55 Hit 54.1% 5.74e-06
2630 KP13_02773 Biopolymer transport protein exbB exbB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.55 No Hit 0.0% —
2631 KP13_02333 Cobalt-precorrin-6A reductase cbiJ AlphaFold + ColabFold –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0016994Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+.
No map 0.55 No Hit 0.0% —
2632 KP13_01989 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0033194Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
No map 0.55 No Hit 0.0% —
2633 KP13_31992 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.549 No Hit 0.0% —
2634 KP13_06934 hypothetical protein AlphaFold + ColabFold – – No map 0.549 No Hit 0.0% —
2635 KP13_04360 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.549 No Hit 0.0% —
2636 KP13_02958 Biotin carboxyl carrier protein of acetyl-CoA carboxylase accB AlphaFold + ColabFold –
GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No map 0.549 Hit 37.5% 3.10e-06
2637 KP13_01577 Mannose permease IID component manZ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.549 No Hit 0.0% —
2638 KP13_01235 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.549 No Hit 0.0% —
2639 KP13_00241 Xylulose kinase xylB AlphaFold + ColabFold
2.7.1.17
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
No map 0.549 Hit 31.4% 5.41e-07
2640 KP13_31579 HTH-type transcriptional regulator merD merD AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.548 No Hit 0.0% —
2641 KP13_05921 hypothetical protein AlphaFold + ColabFold – – No map 0.548 No Hit 0.0% —
2642 KP13_03971 putative transposase AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872Binding to a metal ion. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +14 total
No map 0.548 No Hit 0.0% —
2643 KP13_03372 putative 2-hydroxyacid dehydrogenase AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0047545Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. +25 total
No map 0.548 Hit 41.7% 2.65e-24
2644 KP13_03331 hypothetical protein AlphaFold + ColabFold – – No map 0.548 No Hit 0.0% —
2645 KP13_03214 hypothetical protein AlphaFold + ColabFold – – No map 0.548 No Hit 0.0% —
2646 KP13_01484 hypothetical protein AlphaFold + ColabFold – – No map 0.548 No Hit 0.0% —
2647 KP13_00912 hypothetical protein AlphaFold + ColabFold – – No map 0.548 No Hit 0.0% —
2648 KP13_00715 TsgA-like protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.548 No Hit 0.0% —
2649 KP13_00641 High-affinity branched-chain amino acid transport system permease protein livH livH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +811 total
No map 0.548 No Hit 0.0% —
2650 KP13_32226 putative amino acid/polyamine transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.547 Hit 30.9% 4.19e-10
Page of 208 · 5192 total proteins