Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
651 KP13_01638 Alpha,alpha-trehalose-phosphate synthase UDP-forming otsA AlphaFold + ColabFold
2.4.1.15
GO:0003825Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose.
0.903 No Hit 0.0% —
652 KP13_01119 Octaprenyl-diphosphate synthase ispB AlphaFold + ColabFold –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
0.903 Hit 31.0% 8.67e-42
653 KP13_05005 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.902 No Hit 0.0% —
654 KP13_04768 MATE family transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +36 total
0.902 No Hit 0.0% —
655 KP13_03526 Inositol 2-dehydrogenase idhA AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.902 No Hit 0.0% —
656 KP13_02588 Nitric oxide reductase FlRd-NAD(+) reductase norW AlphaFold + ColabFold
1.18.1.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016731Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.902 Hit 33.1% 1.13e-09
657 KP13_01899 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC AlphaFold + ColabFold –
GO:0008759OBSOLETE. Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.
0.902 No Hit 0.0% —
658 KP13_00689 Osmolarity sensor protein envZ envZ AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.902 No Hit 0.0% —
659 KP13_00101 PEP-sugar phosphotransferase enzyme IIC subunit AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
0.902 No Hit 0.0% —
660 KP13_05397 N-succinylglutamate 5-semialdehyde dehydrogenase AlphaFold + ColabFold
1.2.1.71
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.901 Hit 34.4% 1.37e-06
661 KP13_02509 YfaZ family protein AlphaFold + ColabFold – – 0.901 No Hit 0.0% —
662 KP13_01160 Anaerobic dimethyl sulfoxide reductase chain AlphaFold + ColabFold –
GO:0019645A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009390An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. +25 total
0.901 No Hit 0.0% —
663 KP13_04841 hypothetical protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
0.9 No Hit 0.0% —
664 KP13_03503 Aldo/keto reductase family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.9 Hit 34.8% 2.71e-09
665 KP13_01623 putative transcriptional regulatory protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.9 Hit 31.2% 2.73e-32
666 KP13_32150 Transcriptional regulator AcoK AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005515Binding to a protein. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.899 No Hit 0.0% —
667 KP13_01091 luciferase-like monooxygenase AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.899 No Hit 0.0% —
668 KP13_00823 Phosphoribosylformylglycinamidine synthase purL AlphaFold + ColabFold
6.3.5.3
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004642Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.899 Hit 46.5% 1.55e-06
669 KP13_04139 hypothetical protein AlphaFold + ColabFold – – 0.898 No Hit 0.0% —
670 KP13_01898 Secretion monitor secM AlphaFold + ColabFold –
GO:0045182Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.898 No Hit 0.0% —
671 KP13_01075 hypothetical protein AlphaFold + ColabFold – – 0.898 No Hit 0.0% —
672 KP13_05548 ABC transporter permease family AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.897 No Hit 0.0% —
673 KP13_04508 N-hydroxyarylamine O-acetyltransferase nhoA AlphaFold + ColabFold
2.3.1.118
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0004060Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. GO:0046990Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.
0.897 Hit 26.3% 1.09e-17
674 KP13_04015 hypothetical protein AlphaFold + ColabFold – – 0.897 No Hit 0.0% —
675 KP13_03135 putative phosphatidic acid phosphatase protein in cps region AlphaFold + ColabFold – – 0.897 No Hit 0.0% —
Page of 208 · 5192 total proteins