Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
801 KP13_03318 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase ubiF AlphaFold + ColabFold –
GO:0016709Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +58 total
0.903 Hit 36.0% 2.61e-09
802 KP13_03469 Sugar isomerase (SIS) domain-containing protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
0.178 Hit 26.0% 2.61e-09
803 KP13_21046 Uracil phosphoribosyltransferase upp Experimental + ColabFold –
GO:0006223Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. GO:0004845Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
0.314 Hit 28.7% 2.62e-09
804 KP13_04359 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.524 Hit 36.7% 2.63e-09
805 KP13_31880 Malonyl-CoA O-methyltransferase BioC bioC AlphaFold + ColabFold
2.1.1.197
GO:0010340Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +36 total
0.828 Hit 25.3% 2.66e-09
806 KP13_03503 Aldo/keto reductase family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.9 Hit 34.8% 2.71e-09
807 KP13_04873 Spermidine/putrescine import ATP-binding protein potA AlphaFold + ColabFold
7.6.2.11
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +69 total
0.453 Hit 45.7% 2.77e-09
808 KP13_00717 Peptidyl-prolyl cis-trans isomerase A ppiA AlphaFold + ColabFold
5.2.1.8
GO:0000413The modification of a protein by cis-trans isomerization of a proline residue. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +14 total
0.631 Hit 44.2% 2.78e-09
809 KP13_04314 Ribosomal RNA large subunit methyltransferase F rlmF AlphaFold + ColabFold
2.1.1.181
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008988Catalysis of the reaction: adenosine in rRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +36 total
0.798 Hit 34.4% 2.80e-09
810 KP13_01561 Septum site-determining protein minD minD AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.289 Hit 26.8% 2.81e-09
811 KP13_00192 putative glycosyltransferase in waa region AlphaFold + ColabFold –
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
0.611 Hit 33.0% 2.85e-09
812 KP13_00582 Cation-efflux pump fieF fieF AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +1013 total
0.985 Hit 23.5% 2.86e-09
813 KP13_02409 cytotoxic necrotizing factor-like protein AlphaFold + ColabFold –
GO:0005507Binding to a copper (Cu) ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.466 Hit 37.5% 2.99e-09
814 KP13_32213 Inositol-1-monophosphatase AlphaFold + ColabFold –
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. GO:0006020The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +14 total
0.117 Hit 34.9% 3.05e-09
815 KP13_03215 Stringent starvation protein A sspA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.272 Hit 32.2% 3.12e-09
816 KP13_13347 Uridine phosphorylase udp AlphaFold + ColabFold
2.4.2.3
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.668 Hit 30.4% 3.22e-09
817 KP13_31527 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase mhpA AlphaFold + ColabFold
1.14.13.127
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0019622The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. GO:0008688Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. +14 total
0.986 Hit 22.9% 3.42e-09
818 KP13_04785 patatin like phospholipase AlphaFold + ColabFold –
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. +25 total
0.825 Hit 24.3% 3.59e-09
819 KP13_04616 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.407 Hit 32.9% 3.65e-09
820 KP13_03923 Sodium/proline symporter putP AlphaFold + ColabFold –
GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005298Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). +69 total
0.847 Hit 24.5% 4.00e-09
821 KP13_05166 Glutathione S-transferase AlphaFold + ColabFold – – 0.491 Hit 29.9% 4.08e-09
822 KP13_00237 Xylose import ATP-binding protein xylG xylG AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015614Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in). GO:0015753The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. +36 total
0.726 Hit 33.7% 4.20e-09
823 KP13_04980 hypothetical protein AlphaFold + ColabFold –
GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872Binding to a metal ion.
0.242 Hit 42.9% 4.27e-09
824 KP13_01329 Putative sulfate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.915 Hit 33.1% 4.47e-09
825 KP13_00993 NADH-quinone oxidoreductase subunit A nuoA AlphaFold + ColabFold –
GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
0.659 Hit 37.9% 4.77e-09
Page of 234 · 5842 total proteins