Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2351 KP13_01608 Phosphoribosylglycinamide formyltransferase 2 purT AlphaFold + ColabFold
6.3.1.21
GO:0009152The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0046872Binding to a metal ion. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +69 total
No map 0.36 No Hit 0.0% —
2352 KP13_01609 KHG/KDPG aldolase eda AlphaFold + ColabFold
4.1.2.14
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008675Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
No map 0.94 No Hit 0.0% —
2353 KP13_01610 Phosphogluconate dehydratase edd AlphaFold + ColabFold
4.2.1.12
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0009255A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.725 No Hit 0.0% —
2354 KP13_01612 hypothetical protein AlphaFold + ColabFold – – No map 0.572 No Hit 0.0% —
2355 KP13_01613 HTH-type transcriptional regulator hexR hexR AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.617 No Hit 0.0% —
2356 KP13_01616 putative metalloprotease AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +14 total
No map 0.29 No Hit 0.0% —
2357 KP13_01617 High-affinity zinc uptake system protein znuA znuA AlphaFold + ColabFold –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046872Binding to a metal ion. GO:0006829The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.477 No Hit 0.0% —
2358 KP13_01619 High-affinity zinc uptake system membrane protein znuB znuB AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.691 No Hit 0.0% —
2359 KP13_01621 Holliday junction ATP-dependent DNA helicase ruvA ruvA AlphaFold + ColabFold –
GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0009379A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. +811 total
No map 0.515 No Hit 0.0% —
2360 KP13_01622 Crossover junction endodeoxyribonuclease ruvC ruvC AlphaFold + ColabFold
3.1.21.10
GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +69 total
No map 0.304 No Hit 0.0% —
2361 KP13_01626 putative isochorismatase family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.723 No Hit 0.0% —
2362 KP13_01628 hypothetical protein ColabFold – – No map 0.488 No Hit 0.0% —
2363 KP13_01629 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.554 No Hit 0.0% —
2364 KP13_01630 tRNA (cmo5U34)-methyltransferase cmoA AlphaFold + ColabFold
2.1.3.-
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0016743Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
No map 0.889 No Hit 0.0% —
2365 KP13_01631 tRNA (mo5U34)-methyltransferase cmoB AlphaFold + ColabFold
2.5.1.-
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
No map 0.744 No Hit 0.0% —
2366 KP13_01633 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.601 No Hit 0.0% —
2367 KP13_01635 Unsaturated rhamnogalacturonyl hydrolase Experimental + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.302 No Hit 0.0% —
2368 KP13_01636 putative symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +14 total
No map 0.703 No Hit 0.0% —
2369 KP13_01637 Universal stress protein C uspC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.757 No Hit 0.0% —
2370 KP13_01638 Alpha,alpha-trehalose-phosphate synthase UDP-forming otsA AlphaFold + ColabFold
2.4.1.15
GO:0003825Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose.
No map 0.903 No Hit 0.0% —
2371 KP13_01639 Trehalose-phosphate phosphatase otsB AlphaFold + ColabFold
3.1.3.12
GO:0004805Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. +14 total
No map 0.613 No Hit 0.0% —
2372 KP13_01640 L-arabinose transport system permease protein araH araH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.557 No Hit 0.0% —
2373 KP13_01642 L-arabinose-binding periplasmic protein araF AlphaFold + ColabFold –
GO:0042882The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.576 No Hit 0.0% —
2374 KP13_01644 hypothetical protein AlphaFold + ColabFold – – No map 0.775 No Hit 0.0% —
2375 KP13_01646 hypothetical protein AlphaFold + ColabFold – – No map 0.431 No Hit 0.0% —
Page of 234 · 5842 total proteins