Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2376 KP13_05588 D-lactate dehydrogenase ldhA AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.592 Hit 41.0% 7.84e-23
2377 KP13_05484 Sulfite exporter TauE family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.592 No Hit 0.0% —
2378 KP13_05314 Glyoxalase/bleomycin resistance protein/dioxygenase domain-containing protein AlphaFold + ColabFold – – No map 0.592 No Hit 0.0% —
2379 KP13_03979 putative lipoprotein AlphaFold + ColabFold – – No map 0.592 No Hit 0.0% —
2380 KP13_02537 putative DNA helicase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0006468The process of introducing a phosphate group on to a protein. +36 total
No map 0.592 Hit 37.8% 1.33e-09
2381 KP13_01679 hypothetical protein AlphaFold + ColabFold – – No map 0.592 No Hit 0.0% —
2382 KP13_01008 putative disulfide bond reductase AlphaFold + ColabFold –
GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
No map 0.592 No Hit 0.0% —
2383 KP13_00988 NADH-quinone oxidoreductase subunit G nuoG AlphaFold + ColabFold
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +811 total
No map 0.592 Hit 24.9% 4.23e-46
2384 KP13_00554 Argininosuccinate lyase argH AlphaFold + ColabFold
4.3.2.1
GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. +14 total
No map 0.592 Hit 70.0% 9.84e-18
2385 KP13_05026 hypothetical protein AlphaFold + ColabFold – – No map 0.591 No Hit 0.0% —
2386 KP13_04224 Cold shock-like protein cspD cspD AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.591 Hit 40.3% 4.45e-07
2387 KP13_03304 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.591 No Hit 0.0% —
2388 KP13_00122 hypothetical protein AlphaFold + ColabFold – – No map 0.591 No Hit 0.0% —
2389 KP13_31500 Glutamate racemase murI AlphaFold + ColabFold
5.1.1.3
GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. GO:0008881Catalysis of the reaction: L-glutamate = D-glutamate. +47 total
No map 0.59 No Hit 0.0% —
2390 KP13_06708 putative inner membrane protein AlphaFold + ColabFold – – No map 0.59 No Hit 0.0% —
2391 KP13_01247 BtrG-like domain-containing protein AlphaFold + ColabFold –
GO:0061929Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.59 No Hit 0.0% —
2392 KP13_03626 hypothetical protein AlphaFold + ColabFold –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.589 No Hit 0.0% —
2393 KP13_02747 Nucleoside permease nupG nupG AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. +69 total
No map 0.589 No Hit 0.0% —
2394 KP13_02232 Type 1 fimbriae regulatory protein fimB fimB AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.589 No Hit 0.0% —
2395 KP13_01321 Inosose dehydratase iolE AlphaFold + ColabFold
4.2.1.44
GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. GO:0050114Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O. GO:0030145Binding to a manganese ion (Mn). +14 total
No map 0.589 No Hit 0.0% —
2396 KP13_06749 DNA-binding protein stpA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map 0.588 No Hit 0.0% —
2397 KP13_03558 hypothetical protein AlphaFold + ColabFold – – No map 0.588 No Hit 0.0% —
2398 KP13_02647 hypothetical protein AlphaFold + ColabFold – – No map 0.588 No Hit 0.0% —
2399 KP13_01276 Toxin RelE relE AlphaFold + ColabFold – – No map 0.588 No Hit 0.0% —
2400 KP13_01032 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB AlphaFold + ColabFold
2.3.1.41
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +14 total
No map 0.588 Hit 33.8% 4.69e-62
Page of 208 · 5192 total proteins