Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2376 KP13_01647 Major facilitator superfamily transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.941 No Hit 0.0% —
2377 KP13_01648 Ribose/galactose isomerase family protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
No map 0.583 No Hit 0.0% —
2378 KP13_01649 hypothetical protein AlphaFold + ColabFold – – No map 0.48 No Hit 0.0% —
2379 KP13_01650 Ferritin-1 ftnA AlphaFold + ColabFold
1.16.3.2
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.587 No Hit 0.0% —
2380 KP13_01651 hypothetical protein AlphaFold + ColabFold – – No map 0.542 No Hit 0.0% —
2381 KP13_01653 nucleic acid binding domain-containing protein AlphaFold + ColabFold – – No map 0.71 No Hit 0.0% —
2382 KP13_01654 Dihydrodipicolinate synthase dapA AlphaFold + ColabFold
4.3.3.7
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+.
No map 0.428 No Hit 0.0% —
2383 KP13_01656 UvrABC system protein C uvrC AlphaFold + ColabFold –
GO:0009381Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind. GO:0006289A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). GO:0005515Binding to a protein. +58 total
No map 0.303 No Hit 0.0% —
2384 KP13_01657 Response regulator uvrY uvrY AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.424 No Hit 0.0% —
2385 KP13_01658 hypothetical protein AlphaFold + ColabFold – – No map 0.355 No Hit 0.0% —
2386 KP13_01659 Regulatory protein sdiA sdiA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.855 No Hit 0.0% —
2387 KP13_01661 Inner membrane amino-acid ABC transporter permease protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
No map 0.866 No Hit 0.0% —
2388 KP13_01662 D-cysteine desulfhydrase dcyD AlphaFold + ColabFold
4.4.1.15
GO:0019148Catalysis of the reaction: D-cysteine + H2O = hydrogen sulfide + pyruvate + NH4+ + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046416The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids.
No map 0.911 No Hit 0.0% —
2389 KP13_01664 hypothetical protein AlphaFold + ColabFold – – No map 0.201 No Hit 0.0% —
2390 KP13_01667 reverse transcriptase domain-containing protein AlphaFold + ColabFold – – No map 0.517 No Hit 0.0% —
2391 KP13_01668 phage site-specific recombinase AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.954 No Hit 0.0% —
2392 KP13_01669 hypothetical protein AlphaFold + ColabFold – – No map 0.315 No Hit 0.0% —
2393 KP13_01670 hypothetical protein AlphaFold + ColabFold – – No map 0.733 No Hit 0.0% —
2394 KP13_01671 hypothetical protein AlphaFold + ColabFold – – No map 0.961 No Hit 0.0% —
2395 KP13_01672 DNA replication terminus site-binding protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.803 No Hit 0.0% —
2396 KP13_01673 hypothetical protein AlphaFold + ColabFold – – No map 0.842 No Hit 0.0% —
2397 KP13_01674 hypothetical protein AlphaFold + ColabFold – – No map 0.395 No Hit 0.0% —
2398 KP13_01675 hypothetical protein AlphaFold + ColabFold – – No map 0.669 No Hit 0.0% —
2399 KP13_01676 hypothetical protein AlphaFold + ColabFold – – No map 0.984 No Hit 0.0% —
2400 KP13_01677 hypothetical protein AlphaFold + ColabFold – – No map 0.759 No Hit 0.0% —
Page of 234 · 5842 total proteins