Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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9 / 5572 proteins

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Applied filters EC Number: 3.5.1.2

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EC Number: 3.5.1.2 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA0845 neutral ceramidase PA0845 Experimental + AlphaFold DB model
3.5.1.23
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. +58 total
No map 0.919 Hit 36.1% 3.16e-129
2 PA4947 N-acetylmuramoyl-L-alanine amidase PA4947, amiB AlphaFold DB model
3.5.1.28
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0008745Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
No map 0.648 No Hit N/A —
3 PA5538 N-acetylmuramoyl-L-alanine amidase amiA, PA5538 AlphaFold DB model
3.5.1.28
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0008745Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
No map 0.604 No Hit N/A —
4 PA0807 protein AmpDh3 ampDh3, PA0807 Experimental + AlphaFold DB model
3.5.1.28
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0046872Binding to a metal ion. +47 total
No map 0.588 No Hit N/A —
5 PA5485 protein AmpDh2 PA5485, ampDh2 Experimental + AlphaFold DB model
3.5.1.28
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0046872Binding to a metal ion. +47 total
No map 0.572 No Hit N/A —
6 PA1638 glutaminase PA1638, glsA AlphaFold DB model
3.5.1.2
GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. GO:0006543The chemical reactions and pathways resulting in the breakdown of L-glutamine. +14 total
No map 0.533 Hit 41.7% 2.14e-16
7 PA4522 N-acetyl-anhydromuranmyl-L-alanine amidase PA4522, ampD AlphaFold DB model
3.5.1.28
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0046872Binding to a metal ion. +47 total
No map 0.411 No Hit N/A —
8 PA3152 imidazole glycerol phosphate synthase subunit HisH hisH, PA3152, hisH2 AlphaFold DB model
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +47 total
No map 0.22 No Hit N/A —
9 PA5142 imidazole glycerol phosphate synthase subunit HisH PA5142, hisH1 AlphaFold DB model
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +36 total
No map No pocket No Hit N/A —
Page 1 of 1 · 9 total proteins