Metabolic network

VK055_4143

glycine cleavage system H protein

Back to protein
Network centrality 0.16903 top 98.7%
Chokepoint No

Metabolic context: more central than 98.7% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism Lipoic acid metabolism One carbon pool by folate

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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Pathway
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

GCVT-RXN

EC 2.1.2.10 · GCVT-RXN · reversible · 2 isoenzymes

a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine a tetrahydrofolate
⇌
a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine a 5,10-methylenetetrahydrofolate ammonium

RXN-8629

EC 1.8.1.4 · RXN-8629 · reversible · 3 isoenzymes

a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine NAD+
⇌
a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine NADH H+

GCVP-RXN

EC 1.4.4.2 · GCVP-RXN · reversible · 2 isoenzymes

glycine a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine H+
⇌
a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine CO2

GCVMULTI-RXN

EC 1.4.1.27 · GCVMULTI-RXN · reversible · no isoenzyme backup

glycine a tetrahydrofolate NAD+
⇌
a 5,10-methylenetetrahydrofolate ammonium CO2 NADH

Imported from KpATCC43816.sbml · 2026-07-09