Protein profile

KP13_02080

hypothetical protein

Genome: KpKP13

Gene: AHE46083.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GND3
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Amino acids 94
Annotations 7
Features 12
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
KP13_02080
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46083.1
Status
annotated
Amino acids
94
Structure source
AlphaFold + ColabFold
EC
2.4.2.1 2.4.2.2
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975 Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731 Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. GO:0004850 Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
59.14
DEG E-value
2.24e-34
Localization
Unknown
ColabFold pLDDT
98.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure A0A0H3GND3
Pocket Pocket 1
P2Rank 0.677
Structure A0A0H3GND3
Pocket Pocket 1
ColabFold model
FPocket 0.795 · Pocket 1
P2Rank 0.71 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 5 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

5
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0047975 Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine.
  • GO:0004731 Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
  • GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.
  • GO:0004850 Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 94 SUPERFAMILY SSF51182 RmlC-like cupins
1 94 InterPro IPR011051 RmlC-like cupin domain superfamily
4 93 CDD cd20296 cupin_PpnP-like
3 93 Pfam PF06865 Pyrimidine/purine nucleoside phosphorylase
3 93 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
1 94 Hamap MF_01537 Pyrimidine/purine nucleoside phosphorylase [ppnP].
1 94 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
2 94 PANTHER PTHR36540 PYRIMIDINE/PURINE NUCLEOSIDE PHOSPHORYLASE
2 94 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
1 93 Gene3D G3DSA:2.60.120.10 Jelly Rolls
1 93 InterPro IPR014710 RmlC-like jelly roll fold
1 94 FunFam G3DSA:2.60.120.10:FF:000016 Pyrimidine/purine nucleoside phosphorylase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GND3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02080
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.827

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.08 0.594