Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
6 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.4.2.1

Search query No active search

Rows per page 25

Rows
Active criteria 1
EC Number: 2.4.2.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_02080 hypothetical protein AlphaFold + ColabFold
2.4.2.1 2.4.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. +25 total
0.827 No Hit 0.0% —
2 KP13_02013 Purine nucleoside phosphorylase deoD-type deoD AlphaFold + ColabFold
2.4.2.1
GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0004731Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
0.684 No Hit 0.0% —
3 KP13_01020 Amidophosphoribosyltransferase purF AlphaFold + ColabFold
2.4.2.14
GO:0009113The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0004044Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.392 Hit 40.3% 5.36e-20
4 KP13_03767 ATP phosphoribosyltransferase hisG AlphaFold + ColabFold
2.4.2.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0003879Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. +25 total
0.29 No Hit 0.0% —
5 KP13_01888 Nicotinate-nucleotide pyrophosphorylase carboxylating nadC AlphaFold + ColabFold
2.4.2.19
GO:0004514Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). +25 total
0.283 Hit 38.6% 1.06e-13
6 KP13_31497 Orotate phosphoribosyltransferase pyrE AlphaFold + ColabFold
2.4.2.10
GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.116 Hit 31.2% 3.16e-08
Page 1 of 1 · 6 total proteins