Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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6 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.4.2.2

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Active criteria 1
EC Number: 2.4.2.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_02080 hypothetical protein AlphaFold + ColabFold
2.4.2.1 2.4.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. +25 total
0.827 No Hit 0.0% —
2 KP13_02055 Queuine tRNA-ribosyltransferase AlphaFold + ColabFold
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0008479Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA. GO:0101030OBSOLETE. The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. +47 total
0.64 Hit 48.9% 6.42e-40
3 KP13_02342 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.639 No Hit 0.0% —
4 KP13_01428 Queuine tRNA-ribosyltransferase tgt AlphaFold + ColabFold
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). +14 total
0.383 Hit 33.3% 4.67e-15
5 KP13_02913 Xanthine phosphoribosyltransferase gpt AlphaFold + ColabFold
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.257 No Hit 0.0% —
6 KP13_04750 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.256 No Hit 0.0% —
Page 1 of 1 · 6 total proteins