2-ISOPROPYLMALATESYN-RXN
EC 2.3.3.13 · R01213 · 2-ISOPROPYLMALATESYN-RXN · not reversible
KEGG:map00290
Valine, leucine and isoleucine biosynthesis
KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Reactions
15
Proteins
15
Metabolites
28
Chokepoints
5
Pathway map
Reaction-to-metabolite flow reconstructed from the imported SBML participants.
Chokepoint reaction
Metabolite
⇌ Reversible reaction
Currency metabolites hidden
Computing layout…
Connected pathways
Other pathways in this genome that share reactions with this one.
MODEL
Unassigned metabolic reactions
20 shared
KEGG
Valine, leucine and isoleucine degradation
5 shared
KEGG
Pantothenate and CoA biosynthesis
4 shared
KEGG
Glycine, serine and threonine metabolism
1 shared
KEGG
Propanoate metabolism
1 shared
KEGG
Aminoacyl-tRNA biosynthesis
1 shared
KEGG
Butanoate metabolism
1 shared
Reaction table
Catalyzed reactions, mapped genes, and SBML substrates/products.
3-ISOPROPYLMALDEHYDROG-RXN
EC - · R04426 · 3-ISOPROPYLMALDEHYDROG-RXN · not reversible
(2R,3S)-3-isopropylmalate
NAD+
→
(2S)-2-isopropyl-3-oxosuccinate
H+
NADH
3-ISOPROPYLMALISOM-RXN
EC - · R03968 · 3-ISOPROPYLMALISOM-RXN · reversible
2-isopropylmaleate
H2O
⇌
(2S)-2-isopropylmalate
ACETOLACTSYN-RXN
EC 2.2.1.6 · R00226 · ACETOLACTSYN-RXN · not reversible
pyruvate
H+
→
(S)-2-acetolactate
CO2
ACETOOHBUTSYN-RXN
EC 2.2.1.6 · R08648 · ACETOOHBUTSYN-RXN · not reversible
2-oxobutanoate
pyruvate
H+
→
(S)-2-aceto-2-hydroxybutanoate
CO2
BRANCHED-CHAINAMINOTRANSFERILEU-RXN
EC 2.6.1.42 · R02199 · BRANCHED-CHAINAMINOTRANSFERILEU-RXN · not reversible
(3S)-3-methyl-2-oxopentanoate
L-glutamate
→
2-oxoglutarate
L-isoleucine
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
EC 2.6.1.42, 2.6.1.6 · R01090 · BRANCHED-CHAINAMINOTRANSFERLEU-RXN · reversible
2-oxoglutarate
L-leucine
⇌
4-methyl-2-oxopentanoate
L-glutamate
BRANCHED-CHAINAMINOTRANSFERVAL-RXN
EC 2.6.1.42 · R01214 · BRANCHED-CHAINAMINOTRANSFERVAL-RXN · reversible
2-oxoglutarate
L-valine
⇌
3-methyl-2-oxobutanoate
L-glutamate
DIHYDROXYISOVALDEHYDRAT-RXN
EC 4.2.1.9 · R04441 · DIHYDROXYISOVALDEHYDRAT-RXN · not reversible
(2R)-2,3-dihydroxy-3-methylbutanoate
→
3-methyl-2-oxobutanoate
H2O
DIHYDROXYMETVALDEHYDRAT-RXN
EC 4.2.1.9 · R05070 · DIHYDROXYMETVALDEHYDRAT-RXN · not reversible
(R)-2,3-dihydroxy-3-methylpentanoate
→
(3S)-3-methyl-2-oxopentanoate
H2O
(2R,3S)-3-isopropylmalate
⇌
(2S)-2-isopropylmalate
(2S)-2-isopropyl-3-oxosuccinate
H+
→
4-methyl-2-oxopentanoate
CO2
No mapped protein
(2R,3S)-3-isopropylmalate
⇌
2-isopropylmaleate
H2O
THREDEHYD-RXN
EC 4.3.1.19 · R00996 · THREDEHYD-RXN · not reversible
L-threonine
→
2-oxobutanoate
ammonium
VALINE-PYRUVATE-AMINOTRANSFER-RXN
EC 2.6.1.66 · R01215 · VALINE-PYRUVATE-AMINOTRANSFER-RXN · reversible
L-valine
pyruvate
⇌
3-methyl-2-oxobutanoate
L-alanine