Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4645 / 5081 proteins Structure: AlphaFold

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Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
326 VK055_4849 NADH:ubiquinone oxidoreductase, membrane subunitN nuoN AlphaFold DB model + ColabFold model
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +36 total
Mapped 3 0.953 Hit 21.9% 7.77e-12
327 VK055_4742 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.953 No Hit 0.0% —
328 VK055_4254 acetyl-CoA C-acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +14 total
No map 0.952 Hit 49.3% 2.06e-12
329 VK055_2526 dimethyladenosine transferase ksgA AlphaFold DB model + ColabFold model
2.1.1.182
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0000179Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. GO:0000154The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. +47 total
No map 0.952 Hit 32.7% 9.00e-16
330 VK055_0229 nitrate ABC transporter, permease protein ntrB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0015706The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.952 No Hit 0.0% —
331 VK055_3441 putative oxidoreductase, Zn-dependent and NAD(P)-binding protein AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
Mapped 1 0.951 Hit 31.6% 1.78e-08
332 VK055_3182 4-alpha-L-fucosyltransferase wecF AlphaFold DB model + ColabFold model
2.4.1.325
GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0008417Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. GO:0036065OBSOLETE. The covalent attachment of a fucosyl group to an acceptor molecule. +25 total
Chokepoint 1 0.951 No Hit 0.0% —
333 VK055_2442 spermidine synthase speE AlphaFold DB model + ColabFold model
2.5.1.16
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004766Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. +14 total
Chokepoint 1 0.951 Hit 45.0% 9.13e-27
334 VK055_1866 rod shape-determining protein RodA mrdB AlphaFold DB model + ColabFold model
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008360Any process that modulates the surface configuration of a cell. +69 total
No map 0.951 No Hit 0.0% —
335 VK055_4997 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.95 No Hit 0.0% —
336 VK055_3910 mtr tryptophan ArAAP transporter mtr AlphaFold DB model + ColabFold model –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0015173Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. GO:0015801The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.95 No Hit 0.0% —
337 VK055_3077 aceK aceK AlphaFold DB model + ColabFold model
2.7.11.5 3.1.3.-
GO:0008772Catalysis of the reaction: ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H+ + O-phospho-L-seryl-[isocitrate dehydrogenase]. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +710 total
No map 0.95 No Hit 0.0% —
338 VK055_1010 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.95 No Hit 0.0% —
339 VK055_5134 alpha/beta hydrolase family protein AlphaFold DB model + ColabFold model – – No map 0.949 No Hit 0.0% —
340 VK055_4279 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0008779Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +58 total
No map 0.949 Hit 37.0% 2.21e-08
341 VK055_3815 sulfoxide reductase catalytic subunit yedY yedY AlphaFold DB model + ColabFold model
1.8.5.-
GO:0030091The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. GO:0016667Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. +36 total
No map 0.949 No Hit 0.0% —
342 VK055_2938 fused thiol:disulfide interchange protein: membrane electron transporter: activator of DsbC dipZ AlphaFold DB model + ColabFold model
1.8.1.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047134Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +36 total
No map 0.949 No Hit 0.0% —
343 VK055_2787 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0008880Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
No map 0.949 No Hit 0.0% —
344 VK055_2505 sgrR transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.949 No Hit 0.0% —
345 VK055_0755 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.949 No Hit 0.0% —
346 VK055_0287 btuC btuC AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.949 No Hit 0.0% —
347 VK055_4702 neutral zinc metallopeptidase family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.948 No Hit 0.0% —
348 VK055_4626 SURF4 family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.948 No Hit 0.0% —
349 VK055_4617 membrane-bound lytic murein transglycosylase F yfhD AlphaFold DB model + ColabFold model
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016837Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +58 total
No map 0.948 No Hit 0.0% —
350 VK055_4274 PTS system, lactose/cellobiose IIC component family protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
No map 0.948 No Hit 0.0% —
Page of 186 · 4645 total proteins