Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
351 VK055_0877 urea ABC transporter, ATP-binding protein UrtD urtD AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.331 Hit 32.2% 1.03e-20
352 VK055_0674 coenzyme PQQ biosynthesis protein PqqF pqqF AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. GO:0046872Binding to a metal ion. +25 total
No map 0.303 Hit 24.9% 1.11e-20
353 VK055_2509 thiamine ABC transporter, ATP-binding protein thiQ AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +25 total
No map 0.602 Hit 34.9% 1.24e-20
354 VK055_1124 glycosyl hydrolases family 2, sugar binding domain protein AlphaFold DB model + ColabFold model
3.2.1.25
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004567Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. +14 total
No map 0.653 Hit 22.6% 1.59e-20
355 VK055_1018 glutamate dehydrogenase gdhA AlphaFold DB model + ColabFold model –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016639Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +47 total
Mapped 2 0.151 Hit 49.3% 2.32e-20
356 VK055_2512 L-ribulokinase araB AlphaFold DB model + ColabFold model
2.7.1.16
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008741Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +47 total
Chokepoint 2 0.818 Hit 25.4% 2.53e-20
357 VK055_4495 fructose-1-phosphatase yqaB AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
No map 0.346 Hit 35.6% 2.55e-20
358 VK055_0207 peptidyl-tRNA hydrolase pth Experimental + ColabFold model –
GO:0004045Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+.
No map 0.769 Hit 35.2% 2.63e-20
359 VK055_4144 glycine dehydrogenase gcvP AlphaFold DB model + ColabFold model
1.4.4.2
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006544The chemical reactions and pathways involving glycine, aminoethanoic acid. +69 total
Mapped 1 0.961 Hit 67.3% 2.72e-20
360 VK055_2588 phosphoserine phosphatase SerB serB AlphaFold DB model + ColabFold model
3.1.3.3
GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0036424Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Mapped 3 0.46 Hit 34.1% 3.25e-20
361 VK055_1456 &gamma-glutamylputrescine synthetase puuA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +36 total
Chokepoint 1 0.115 Hit 25.7% 3.78e-20
362 VK055_2157 bolA transcriptional regulator BolA transcriptional dual regulator bolA ColabFold model – – No map 0.922 Hit 46.3% 3.82e-20
363 VK055_0684 ahpC/TSA family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +25 total
No map 0.932 Hit 31.1% 4.07e-20
364 VK055_4387 23S rRNA (uracil-5-)-methyltransferase RumA rumA AlphaFold DB model + ColabFold model
2.1.1.190
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
Mapped 1 0.677 Hit 34.6% 4.90e-20
365 VK055_4811 amidophosphoribosyltransferase purF AlphaFold DB model + ColabFold model
2.4.2.14
GO:0004044Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. GO:0009113The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0000287Binding to a magnesium (Mg) ion. +14 total
Chokepoint 1 0.392 Hit 40.3% 5.36e-20
366 VK055_3206 branched-chain amino acid aminotransferase ilvE AlphaFold DB model + ColabFold model
2.6.1.42
GO:0009081The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004084Catalysis of the reaction: a branched-chain amino acid (L-leucine, L-isoleucine and L-valine) + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. +811 total
Chokepoint 3 0.683 Hit 28.6% 5.99e-20
367 VK055_1062 ATP-dependent RNA helicase, specific for 23S rRNA AlphaFold DB model + ColabFold model
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. +58 total
No map 0.797 Hit 50.5% 6.67e-20
368 VK055_2227 pyrroline-5-carboxylate reductase proC AlphaFold DB model + ColabFold model
1.5.1.2
GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Mapped 4 0.363 Hit 50.6% 9.52e-20
369 VK055_0765 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.723 Hit 37.4% 9.64e-20
370 VK055_3109 DNA-directed RNA polymerase, beta' subunit rpoC AlphaFold DB model + ColabFold model
2.7.7.6
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0006351The synthesis of an RNA transcript from a DNA template. +47 total
No map 0.373 Hit 44.7% 9.73e-20
371 VK055_0887 beta-galactosidase lacZ AlphaFold DB model + ColabFold model
3.2.1.23
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +69 total
Mapped 34 0.744 Hit 23.5% 1.03e-19
372 VK055_3252 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA AlphaFold DB model + ColabFold model
2.5.1.74
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0046428Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H+ = a 2-demethylmenaquinol + CO2 + diphosphate. +47 total
Mapped 1 0.995 Hit 28.6% 1.07e-19
373 VK055_2394 essential respiratory protein A AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.63 Hit 45.8% 1.13e-19
374 VK055_1245 putative thiosulfate sulfur transferase AlphaFold DB model + ColabFold model –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
Mapped 3 0.142 Hit 28.7% 1.14e-19
375 VK055_1512 putative 2Fe-2S cluster-containing protein AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030151Binding to a molybdenum ion (Mo). +25 total
No map 0.417 Hit 45.2% 1.36e-19
Page of 204 · 5081 total proteins