Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4701 VK055_2723 sugar (Glycoside-Pentoside-Hexuronide) transporter domain protein gph3 AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. +25 total
0.142 No Hit 0.0% —
4702 VK055_1502 macrodomain Ter protein ycbG AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.142 No Hit 0.0% —
4703 VK055_1245 putative thiosulfate sulfur transferase AlphaFold + ColabFold –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
0.142 Hit 28.7% 1.14e-19
4704 VK055_0375 bacterial extracellular solute-binding family protein AlphaFold + ColabFold – – 0.142 No Hit 0.0% —
4705 VK055_2881 hypothetical protein AlphaFold + ColabFold – – 0.14 No Hit 0.0% —
4706 VK055_1107 type VI secretion system protein impB AlphaFold + ColabFold – – 0.14 No Hit 0.0% —
4707 VK055_0626 luciferase-like monooxygenase family protein AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.14 No Hit 0.0% —
4708 VK055_4019 membrane fusogenic activity family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
0.139 No Hit 0.0% —
4709 VK055_1448 quinone oxidoreductase, type IV wrbA AlphaFold + ColabFold
1.6.5.2
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. +69 total
0.139 No Hit 0.0% —
4710 VK055_4910 yejB yejB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.138 No Hit 0.0% —
4711 VK055_4168 3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein AlphaFold + ColabFold
4.1.1.-
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
0.138 No Hit 0.0% —
4712 VK055_3522 pdhR transcriptional dual regulator pdhR2 AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.138 No Hit 0.0% —
4713 VK055_2927 type VII secretion system (T7SS), usher family protein AlphaFold + ColabFold –
GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +25 total
0.137 No Hit 0.0% —
4714 VK055_4316 diol dehydratase-reactivating factor small subunit ddrB AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
4715 VK055_2675 putative CoA-substrate-specific enzyme activase domain protein AlphaFold + ColabFold –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
0.136 No Hit 0.0% —
4716 VK055_0916 hypothetical protein AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
4717 VK055_4160 tyrosine recombinase XerD xerD AlphaFold + ColabFold –
GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +69 total
0.135 No Hit 0.0% —
4718 VK055_4109 rieske [2Fe-2S] domain protein AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.135 Hit 34.3% 2.22e-09
4719 VK055_3566 ankyrin repeat family protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.135 Hit 35.8% 9.58e-07
4720 VK055_2453 pdhR transcriptional dual regulator pdhR AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.135 No Hit 0.0% —
4721 VK055_1316 ACT domain protein AlphaFold + ColabFold – – 0.135 No Hit 0.0% —
4722 VK055_4363 ABC transporter, substrate-binding, aliphatic sulfonates family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
0.134 No Hit 0.0% —
4723 VK055_0694 xylose isomerase-like TIM barrel family protein AlphaFold + ColabFold – – 0.134 No Hit 0.0% —
4724 VK055_0570 hypothetical protein ColabFold – – 0.134 No Hit 0.0% —
4725 VK055_3966 autoinducer 2-degrading protein AlphaFold + ColabFold
5.3.1.32
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002952Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate. +14 total
0.133 No Hit 0.0% —
Page of 204 · 5081 total proteins