Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4701 VK055_1901 bacterial regulatory, Fis family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.035 0.444 No Hit 0.0% —
4702 VK055_1502 macrodomain Ter protein ycbG AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.035 0.142 No Hit 0.0% —
4703 VK055_1350 liporeleasing system, transmembrane, LolC/E family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098797Any protein complex that is part of the plasma membrane. +14 total
No map 0.035 0.296 No Hit 0.0% —
4704 VK055_4814 lysine-arginine-ornithine-binding periplasmic family protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.034 0.166 No Hit 0.0% —
4705 VK055_4178 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No map 0.034 0.419 No Hit 0.0% —
4706 VK055_3901 transcription termination/antitermination L factor nusA AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0031554Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. GO:0031564A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions. +69 total
No map 0.034 0.886 No Hit 0.0% —
4707 VK055_3720 amidohydrolase family protein ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.034 0.419 No Hit 0.0% —
4708 VK055_2401 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.034 0.72 No Hit 0.0% —
4709 VK055_0747 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein AlphaFold DB model + ColabFold model
2.7.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
No map 0.034 0.51 No Hit 0.0% —
4710 VK055_0049 ferritin-like domain protein AlphaFold DB model + ColabFold model –
GO:0008199Binding to a ferric iron ion, Fe(III).
No map 0.034 0.394 No Hit 0.0% —
4711 VK055_2942 PAAR motif family protein AlphaFold DB model + ColabFold model – – No map 0.033 0.2 No Hit 0.0% —
4712 VK055_2650 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit hpaG AlphaFold DB model + ColabFold model –
GO:0018800Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. +14 total
Mapped 3 0.033 0.881 Hit 30.5% 4.86e-16
4713 VK055_1819 transcriptional regulatory, C terminal family protein AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +69 total
No map 0.033 0.556 No Hit 0.0% —
4714 VK055_1701 transketolase, pyrimidine binding domain protein AlphaFold DB model + ColabFold model
2.2.1.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
No map 0.033 0.132 Hit 35.3% 9.40e-24
4715 VK055_1623 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.033 0.459 No Hit 0.0% —
4716 VK055_0983 glpM family protein AlphaFold DB model + ColabFold model – – No map 0.033 0.849 No Hit 0.0% —
4717 VK055_3900 ribosome maturation protein rimP AlphaFold DB model + ColabFold model –
GO:0042274A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
No map 0.032 0.317 No Hit 0.0% —
4718 VK055_3757 50S ribosomal subunit protein L23 rplW AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map 0.032 0.398 Hit 35.9% 4.60e-06
4719 VK055_3706 fimbrial assembly family protein AlphaFold DB model + ColabFold model – – No map 0.032 0.715 No Hit 0.0% —
4720 VK055_2827 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.032 0.808 No Hit 0.0% —
4721 VK055_1884 dsbGreduced AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.032 0.101 No Hit 0.0% —
4722 VK055_1140 putative thiol peroxidase AlphaFold DB model + ColabFold model –
GO:0008379Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.032 0.571 No Hit 0.0% —
4723 VK055_0071 holliday junction DNA helicase RuvA ruvA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +811 total
No map 0.032 0.515 No Hit 0.0% —
4724 VK055_4097 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
No map 0.031 0.351 No Hit 0.0% —
4725 VK055_3781 zn(II)-responsive transcriptional regulator zntR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008270Binding to a zinc ion (Zn). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.031 0.344 No Hit 0.0% —
Page of 204 · 5081 total proteins