Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4676 VK055_0214 outer membrane lipoprotein LolB lolB AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.038 0.662 No Hit 0.0% —
4677 VK055_5161 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.037 0.483 No Hit 0.0% —
4678 VK055_5114 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.037 0.697 No Hit 0.0% —
4679 VK055_5049 bacterial regulatory, arsR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.037 0.189 No Hit 0.0% —
4680 VK055_4395 queuosine biosynthesis protein QueD queD AlphaFold DB model + ColabFold model
4.-.-.-
GO:0070497Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. GO:0046872Binding to a metal ion. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No map 0.037 0.079 Hit 36.3% 9.47e-11
4681 VK055_4231 gram-negative pili assembly chaperone, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.037 0.907 No Hit 0.0% —
4682 VK055_3190 chain length determinant family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. +25 total
No map 0.037 0.78 No Hit 0.0% —
4683 VK055_3004 glutathione S-transferase, C-terminal domain protein AlphaFold DB model + ColabFold model – – No map 0.037 0.27 Hit 25.9% 8.45e-07
4684 VK055_0921 dimethylsulfoxide reductase, chain B dmsB AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.037 0.385 No Hit 0.0% —
4685 VK055_0710 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.037 0.27 No Hit 0.0% —
4686 VK055_0646 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.037 No Hit 0.0% —
4687 VK055_0191 sel1 repeat family protein ColabFold model –
GO:0005515Binding to a protein.
No map 0.037 0.677 No Hit 0.0% —
4688 VK055_4571 ribosomal protein L19 rplS AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map 0.036 0.72 No Hit 0.0% —
4689 VK055_3346 phosphate transport system regulatory protein PhoU phoU AlphaFold DB model + ColabFold model –
GO:0045936Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. GO:0030643A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.036 0.583 No Hit 0.0% —
4690 VK055_3010 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.036 0.658 No Hit 0.0% —
4691 VK055_2380 ribosome recycling factor frr AlphaFold DB model + ColabFold model –
GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043023Binding to a large ribosomal subunit. +14 total
No map 0.036 0.195 Hit 32.2% 6.47e-19
4692 VK055_1621 phage tail tape measure protein, TP901 family, core region AlphaFold DB model + ColabFold model – – No map 0.036 0.902 No Hit 0.0% —
4693 VK055_4181 papC C-terminal domain protein ColabFold model – – No map 0.035 0.025 No Hit 0.0% —
4694 VK055_3703 NUDIX domain protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019144Catalysis of the reaction: ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate. +25 total
No map 0.035 0.306 Hit 29.9% 7.66e-09
4695 VK055_3244 met Apo-repressor, MetJ family protein AlphaFold DB model + ColabFold model –
GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +47 total
No map 0.035 0.264 No Hit 0.0% —
4696 VK055_3093 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.035 0.35 No Hit 0.0% —
4697 VK055_2808 aspartate carbamoyltransferase, regulatory subunit pyrI AlphaFold DB model + ColabFold model –
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0009347A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides. GO:0046872Binding to a metal ion. +14 total
Chokepoint 1 0.035 0.787 No Hit 0.0% —
4698 VK055_2734 hypothetical protein ColabFold model – – No map 0.035 0.849 No Hit 0.0% —
4699 VK055_2148 competence ComEA helix-hairpin-helix repeat region domain protein AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
No map 0.035 0.22 No Hit 0.0% —
4700 VK055_1982 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.035 0.587 No Hit 0.0% —
Page of 204 · 5081 total proteins