Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4651 VK055_2831 PRD domain protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.042 0.794 No Hit 0.0% —
4652 VK055_2265 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.042 0.268 No Hit 0.0% —
4653 VK055_0426 endoribonuclease L-PSP family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.042 0.483 No Hit 0.0% —
4654 VK055_5038 phosphoribosyl-ATP diphosphatase hisE AlphaFold DB model + ColabFold model –
GO:0004635Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0004636Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. +25 total
Chokepoint 1 0.041 0.367 No Hit 0.0% —
4655 VK055_4223 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.041 0.562 No Hit 0.0% —
4656 VK055_3863 PTS IIA-like nitrogen-regulatory protein PtsN ptsN AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.041 0.976 No Hit 0.0% —
4657 VK055_0890 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.041 0.096 No Hit 0.0% —
4658 VK055_4410 5'/3'-nucleotidase SurE surE AlphaFold DB model + ColabFold model
3.1.3.5 3.1.3.6 3.6.1.11
GO:0008252Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
Mapped 10 0.040 0.338 No Hit 0.0% —
4659 VK055_3849 stringent starvation protein A sspA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Chokepoint 2 0.040 0.272 Hit 32.2% 3.12e-09
4660 VK055_3360 DNA polymerase III, beta subunit dnaN AlphaFold DB model + ColabFold model –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +58 total
No map 0.040 0.232 No Hit 0.0% —
4661 VK055_3174 tetratricopeptide repeat family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042168The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005515Binding to a protein. +25 total
No map 0.040 0.844 No Hit 0.0% —
4662 VK055_2267 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.040 0.601 No Hit 0.0% —
4663 VK055_1943 transketolase, pyrimidine binding domain protein AlphaFold DB model + ColabFold model
2.2.1.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
No map 0.040 0.465 Hit 27.7% 1.87e-17
4664 VK055_5174 phage major capsid protein, HK97 family AlphaFold DB model + ColabFold model – – No map 0.039 0.936 No Hit 0.0% —
4665 VK055_5173 phage prohead protease, HK97 family AlphaFold DB model + ColabFold model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.039 0.707 No Hit 0.0% —
4666 VK055_4576 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.039 0.295 No Hit 0.0% —
4667 VK055_2083 nfeD-like C-terminal, partner-binding family protein AlphaFold DB model + ColabFold model – – No map 0.039 0.407 No Hit 0.0% —
4668 VK055_0635 putative glycosyltransferase AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.039 0.541 No Hit 0.0% —
4669 VK055_0400 cytochrome c-type biogenesis protein CcmH ccmH AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
No map N/A 0.039 No Hit 0.0% —
4670 VK055_3021 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.038 0.745 No Hit 0.0% —
4671 VK055_3005 redox-sensitive transcriptional activator SoxR soxR AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.038 0.411 No Hit 0.0% —
4672 VK055_2620 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015744The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.038 0.701 No Hit 0.0% —
4673 VK055_2411 type II secretion system protein G gspG AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.038 0.146 No Hit 0.0% —
4674 VK055_2121 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.038 0.648 No Hit 0.0% —
4675 VK055_2099 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.038 0.938 No Hit 0.0% —
Page of 204 · 5081 total proteins