Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4651 VK055_3469 spoU rRNA Methylase family protein AlphaFold + ColabFold
2.1.1.34
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.155 Hit 25.3% 1.02e-08
4652 VK055_3455 hypothetical protein AlphaFold + ColabFold – – 0.155 No Hit 0.0% —
4653 VK055_1625 D-alanyl-D-alanine carboxypeptidase family protein AlphaFold + ColabFold –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
0.155 No Hit 0.0% —
4654 VK055_1031 phenylacetate-CoA ligase paaF AlphaFold + ColabFold
6.2.1.30
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0047475Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.155 No Hit 0.0% —
4655 VK055_0848 4-oxalocrotonate tautomerase family enzyme domain protein AlphaFold + ColabFold – – 0.155 No Hit 0.0% —
4656 VK055_3069 manX manX2 Experimental + ColabFold
2.7.1.206
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.153 No Hit 0.0% —
4657 VK055_2038 hypothetical protein AlphaFold + ColabFold – – 0.153 No Hit 0.0% —
4658 VK055_5019 glycosyl transferases group 1 family protein AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
0.152 Hit 37.3% 6.01e-07
4659 VK055_4428 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4660 VK055_3919 hypothetical protein AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.152 Hit 30.0% 3.54e-25
4661 VK055_2821 qin prophage antitoxin of the RelE-RelB toxin-antitoxin system and transcriptional repressor of relBEF relB AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template.
0.152 No Hit 0.0% —
4662 VK055_0564 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4663 VK055_0222 chaB family protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4664 VK055_0015 HD domain protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4665 VK055_4747 glucose-specific phosphotransferase enzyme IIA component crr AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.151 No Hit 0.0% —
4666 VK055_4633 hypothetical protein AlphaFold + ColabFold – – 0.151 No Hit 0.0% —
4667 VK055_4070 fimbrial family protein ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
0.151 No Hit 0.0% —
4668 VK055_2203 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
0.151 No Hit 0.0% —
4669 VK055_1018 glutamate dehydrogenase gdhA AlphaFold + ColabFold –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016639Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +47 total
0.151 Hit 49.3% 2.32e-20
4670 VK055_0490 hypothetical protein AlphaFold + ColabFold – – 0.151 No Hit 0.0% —
4671 VK055_5060 malonate semialdehyde decarboxylase msaD AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4672 VK055_4581 stationary phase translation inhibitor and ribosome stability factor yfiA AlphaFold + ColabFold –
GO:0044238The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627The small subunit of a ribosome located in the cytosol. GO:0043024Binding to a small ribosomal subunit. +14 total
0.15 No Hit 0.0% —
4673 VK055_4027 hypothetical protein AlphaFold + ColabFold – – 0.15 No Hit 0.0% —
4674 VK055_3783 NAD-dependent glycerol-3-phosphate dehydrogenasefamily protein AlphaFold + ColabFold –
GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.15 No Hit 0.0% —
4675 VK055_3579 cellulose synthase subunit D family protein AlphaFold + ColabFold –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
0.15 No Hit 0.0% —
Page of 204 · 5081 total proteins