Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4726 VK055_3343 phosphate ABC transporter, permease protein PstC pstC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0006817The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.031 0.726 No Hit 0.0% —
4727 VK055_2782 hypothetical protein ColabFold model – – No map N/A 0.031 No Hit 0.0% —
4728 VK055_1979 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.031 0.598 No Hit 0.0% —
4729 VK055_1682 mntR transcriptional repressor AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. +36 total
No map 0.031 0.767 No Hit 0.0% —
4730 VK055_0200 type VI secretion system protein DUF1305 impH2 AlphaFold DB model + ColabFold model – – No map 0.031 0.74 No Hit 0.0% —
4731 VK055_4621 yfhG lipofamily protein AlphaFold DB model + ColabFold model – – No map 0.030 0.194 No Hit 0.0% —
4732 VK055_4340 cobalt ABC transporter, permease protein CbiQ cbiQ AlphaFold DB model + ColabFold model –
GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.030 0.409 No Hit 0.0% —
4733 VK055_4138 yecA family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.030 0.459 No Hit 0.0% —
4734 VK055_3894 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.030 0.857 No Hit 0.0% —
4735 VK055_3106 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold DB model + ColabFold model
2.7.1.205 2.7.1.- 2.7.1.191 +14 total
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map N/A 0.03 No Hit 0.0% —
4736 VK055_2496 leuD leuD AlphaFold DB model + ColabFold model
4.2.1.33
GO:0009316A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. +14 total
Mapped 3 0.030 0.335 No Hit 0.0% —
4737 VK055_2022 putative lipoprotein ColabFold model – – No map N/A 0.03 No Hit 0.0% —
4738 VK055_1987 oxygen-insensitive NAD(P)H nitroreductase nfnB Experimental + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Mapped 1 0.030 0.435 No Hit 0.0% —
4739 VK055_0494 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.030 0.075 No Hit 0.0% —
4740 VK055_0329 hypothetical protein AlphaFold DB model + ColabFold model
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O.
No map 0.030 0.721 No Hit 0.0% —
4741 VK055_4641 iron-sulfur cluster assembly protein iscA AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.029 0.014 Hit 54.8% 7.79e-07
4742 VK055_2522 dnaJ domain protein AlphaFold DB model + ColabFold model –
GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.029 0.968 No Hit 0.0% —
4743 VK055_2270 phosphonate ABC transporter, permease protein PhnE phnE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +25 total
No map 0.029 0.889 No Hit 0.0% —
4744 VK055_1806 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.029 0.93 No Hit 0.0% —
4745 VK055_1800 succinate dehydrogenase, cytochrome b556 subunit sdhC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0045281OBSOLETE. A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. +47 total
Mapped 1 0.029 0.906 No Hit 0.0% —
4746 VK055_1331 potB potB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.029 0.615 No Hit 0.0% —
4747 VK055_0651 putative periplasmic protein AlphaFold DB model + ColabFold model – – No map N/A 0.029 No Hit 0.0% —
4748 VK055_0560 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.029 0.684 No Hit 0.0% —
4749 VK055_4018 glycogen synthesis family protein AlphaFold DB model + ColabFold model –
GO:1902201Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. GO:1900191Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
No map 0.028 0.318 No Hit 0.0% —
4750 VK055_2736 hypothetical protein ColabFold model – – No map 0.028 0.285 No Hit 0.0% —
Page of 204 · 5081 total proteins