Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 VK055_1361 beta-hexosaminidase nagZ AlphaFold DB model + ColabFold model –
GO:0004563Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Chokepoint 15 0.880 0.744 No Hit 0.0% —
1127 VK055_0174 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.880 0.592 No Hit 0.0% —
1128 VK055_0144 alanine racemase alr AlphaFold DB model + ColabFold model
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. +47 total
Mapped 1 0.880 0.121 No Hit 0.0% —
1129 VK055_0137 dsbBreduced dsbB AlphaFold DB model + ColabFold model –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
No map 0.880 0.956 No Hit 0.0% —
1130 VK055_4256 oligogalacturonate lyase AlphaFold DB model + ColabFold model –
GO:0047487Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate. GO:0045490The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. GO:0005515Binding to a protein.
Chokepoint 2 0.879 0.045 No Hit 0.0% —
1131 VK055_3350 HAD hydrolase, IA, variant 1 family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872Binding to a metal ion.
No map 0.879 0.924 No Hit 0.0% —
1132 VK055_3347 lamB porin family protein AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. +58 total
No map 0.879 0.896 No Hit 0.0% —
1133 VK055_2982 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.879 0.593 No Hit 0.0% —
1134 VK055_2085 traB family protein AlphaFold DB model + ColabFold model – – No map 0.879 0.944 No Hit 0.0% —
1135 VK055_5125 major Facilitator Superfamily protein ybtX AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.878 0.885 Hit 27.9% 4.99e-06
1136 VK055_3907 polyribonucleotide nucleotidyltransferase pnp AlphaFold DB model + ColabFold model
2.7.7.8
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003676Binding to a nucleic acid. GO:0006402The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. +58 total
No map 0.878 0.435 Hit 44.6% 2.23e-08
1137 VK055_2899 putative carbohydrate kinase AlphaFold DB model + ColabFold model –
GO:0052855Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + H+ + NAD(P)H + phosphate. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
No map 0.878 0.338 Hit 29.4% 1.65e-12
1138 VK055_1739 imidazolonepropionase hutI AlphaFold DB model + ColabFold model
3.5.2.7
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +69 total
Chokepoint 1 0.878 0.465 Hit 33.8% 1.35e-54
1139 VK055_0627 nickel import ATP-binding protein NikE nikE AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
No map 0.878 0.412 Hit 59.0% 2.24e-07
1140 VK055_0603 nitrate reductase, alpha subunit AlphaFold DB model + ColabFold model
1.7.5.1
GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. +811 total
Mapped 2 0.878 0.885 No Hit 0.0% —
1141 VK055_0419 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.878 No Hit 0.0% —
1142 VK055_4743 cysteine synthase B cysM AlphaFold DB model + ColabFold model
2.5.1.47
GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine.
Chokepoint 3 0.877 0.904 Hit 49.0% 1.38e-23
1143 VK055_4362 5'-3' exonuclease, C-terminal SAM fold family protein AlphaFold DB model + ColabFold model
3.1.-.-
GO:0017108Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0033567The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. +58 total
No map 0.877 0.538 No Hit 0.0% —
1144 VK055_3102 thiazole biosynthesis ThiG family protein AlphaFold DB model + ColabFold model
2.8.1.10
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990107Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. +14 total
No map 0.877 0.41 No Hit 0.0% —
1145 VK055_2488 D-fructose-responsive transcription factor family protein AlphaFold DB model + ColabFold model –
GO:0009750Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.877 0.165 No Hit 0.0% —
1146 VK055_2427 3-methyl-2-oxobutanoate hydroxymethyltransferase panB AlphaFold DB model + ColabFold model
2.1.2.11
GO:0003864Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
Mapped 2 0.877 0.545 No Hit 0.0% —
1147 VK055_1834 transcriptional regulator, ROK family AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.877 0.811 Hit 21.8% 9.86e-10
1148 VK055_0068 dATP pyrophosphohydrolase ntpA AlphaFold DB model + ColabFold model –
GO:0019177Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0008828Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. +47 total
Mapped 1 0.877 0.417 Hit 30.6% 1.28e-07
1149 VK055_4972 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.876 0.715 No Hit 0.0% —
1150 VK055_4468 high-affinity nickel transport protein hoxN AlphaFold DB model + ColabFold model –
GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.876 0.766 No Hit 0.0% —
Page of 204 · 5081 total proteins