Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 VK055_3354 putative transcriptional regulator LysR-type AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.822 No Hit 0.0% —
1127 VK055_1868 penicillin-binding protein 6 dacC AlphaFold + ColabFold
3.4.16.4
GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. +710 total
0.822 No Hit 0.0% —
1128 VK055_1086 bacterial regulatory, tetR family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.822 No Hit 0.0% —
1129 VK055_0338 bacterial transcriptional regulator family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.822 No Hit 0.0% —
1130 VK055_2330 phosphoheptose isomerase gmhA AlphaFold + ColabFold
5.3.1.28
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0008968Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. +47 total
0.821 No Hit 0.0% —
1131 VK055_0281 phenylalanine--tRNA ligase, beta subunit pheT AlphaFold + ColabFold
6.1.1.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.821 Hit 22.7% 8.04e-10
1132 VK055_4101 extracellular deoxyribonuclease AlphaFold + ColabFold –
GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.82 No Hit 0.0% —
1133 VK055_3778 DNA-directed RNA polymerase, alpha subunit rpoA AlphaFold + ColabFold
2.7.7.6
GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. +36 total
0.82 No Hit 0.0% —
1134 VK055_2084 copper-translocating P-type ATPase AlphaFold + ColabFold
7.2.2.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. +1316 total
0.82 Hit 41.3% 1.14e-10
1135 VK055_0864 glyoxylate reductase gyaR AlphaFold + ColabFold
1.1.1.95
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.82 Hit 44.3% 9.47e-16
1136 VK055_0493 superoxide dismutase sodC AlphaFold + ColabFold
1.15.1.1
GO:0005507Binding to a copper (Cu) ion. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +14 total
0.82 Hit 30.9% 2.19e-06
1137 VK055_0147 lytic murein transglycosylase E mltE AlphaFold + ColabFold
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +25 total
0.82 No Hit 0.0% —
1138 VK055_0122 aminodeoxychorismate synthase, component I pabB AlphaFold + ColabFold
2.6.1.85
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. +36 total
0.82 No Hit 0.0% —
1139 VK055_3141 transcriptional activator RfaH rfaH ColabFold –
GO:0140673A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.819 No Hit 0.0% —
1140 VK055_1872 lipoyl synthase lipA AlphaFold + ColabFold
2.8.1.8
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009107The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. GO:0016992Catalysis of the reaction: [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]. +58 total
0.819 Hit 45.1% 4.07e-48
1141 VK055_1671 HAD hydrolase, IIB family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.819 No Hit 0.0% —
1142 VK055_1610 inner membrane of Enterobacteriaceae family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.819 No Hit 0.0% —
1143 VK055_0865 sugar (and other) transporter family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.819 Hit 31.7% 2.63e-07
1144 VK055_4694 peptidase M48 family protein AlphaFold + ColabFold
3.4.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +69 total
0.818 No Hit 0.0% —
1145 VK055_2512 L-ribulokinase araB AlphaFold + ColabFold
2.7.1.16
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008741Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +47 total
0.818 Hit 25.4% 2.53e-20
1146 VK055_1534 protein involved in chromosome partitioning mukE AlphaFold + ColabFold –
GO:0030261The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.818 No Hit 0.0% —
1147 VK055_1359 NADH dehydrogenase II AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
0.818 No Hit 0.0% —
1148 VK055_1041 phenylacetic acid catabolic family protein Experimental + AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0097266Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+.
0.818 No Hit 0.0% —
1149 VK055_0412 NAD-dependent glycerol-3-phosphate dehydrogenasefamily protein AlphaFold + ColabFold
1.1.1.45
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +36 total
0.818 Hit 34.8% 3.56e-15
1150 VK055_0236 narK MFS nitrate/nitrite antiporter narK AlphaFold + ColabFold –
GO:0015707The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015113Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other. +710 total
0.818 No Hit 0.0% —
Page of 204 · 5081 total proteins