Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1076 VK055_4508 binding-protein-dependent transport system innermembrane component family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +47 total
0.83 No Hit 0.0% —
1077 VK055_4372 acyl-CoA dehydrogenase, N-terminal domain protein AlphaFold + ColabFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008470Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. +14 total
0.83 No Hit 0.0% —
1078 VK055_4050 sugar (Glycoside-Pentoside-Hexuronide) transporter domain protein gph7 AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.83 Hit 31.0% 1.47e-13
1079 VK055_3926 galactarate dehydratase garD AlphaFold + ColabFold –
GO:0008867Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046392The chemical reactions and pathways resulting in the breakdown of D-galactarate, the anion of galactaric acid.
0.83 No Hit 0.0% —
1080 VK055_3556 pfkB carbohydrate kinase family protein AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.83 Hit 25.5% 1.75e-06
1081 VK055_1889 2,3-diketo-5-methylthio-1-phosphopentane phosphatase mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 50.0% 8.59e-41
1082 VK055_1630 P2 phage tail completion R family protein ColabFold – – 0.83 No Hit 0.0% —
1083 VK055_0731 putative e3 ubiquitin-protein ligase TRIM33 AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1084 VK055_0183 type IV/VI secretion system, DotU family domain protein AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1085 VK055_4820 NAD dependent epimerase/dehydratase family protein AlphaFold + ColabFold – – 0.829 Hit 46.3% 1.08e-09
1086 VK055_4494 BON domain protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.829 No Hit 0.0% —
1087 VK055_3204 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.829 No Hit 0.0% —
1088 VK055_0978 NAD(P)(+) transhydrogenase (AB-specific), alpha subunit pntA AlphaFold + ColabFold
7.1.1.1
GO:1902600The directed movement of a proton across a membrane. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008746OBSOLETE. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. +47 total
0.829 Hit 57.4% 1.22e-10
1089 VK055_5116 tonB-dependent siderophore receptor family protein fyuA AlphaFold + ColabFold –
GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
0.828 No Hit 0.0% —
1090 VK055_4452 transcriptional repressor of hyc and hyp operonsfamily protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1091 VK055_4359 H+ symporter permease fucP AlphaFold + ColabFold –
GO:0015756The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. GO:0015150Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.828 No Hit 0.0% —
1092 VK055_3801 prokaryotic membrane lipolipid attachment site family protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1093 VK055_2719 hypothetical protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1094 VK055_2298 deoC/LacD aldolase family protein AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.
0.828 No Hit 0.0% —
1095 VK055_1729 putative methyltransferase, enzyme of biotin synthesis AlphaFold + ColabFold
2.1.1.197
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0010340Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. +36 total
0.828 Hit 25.3% 1.96e-09
1096 VK055_1471 glycyl-radical enzyme activating family protein AlphaFold + ColabFold
1.97.1.- 1.97.1.4
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +47 total
0.828 No Hit 0.0% —
1097 VK055_1035 phenylacetate degradation putative enoyl-CoA hydratase PaaB paaB AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.828 Hit 37.1% 7.35e-07
1098 VK055_0940 triphosphoribosyl-dephospho-CoA synthase MdcB mdcB AlphaFold + ColabFold
2.4.2.52
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046917Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +14 total
0.828 No Hit 0.0% —
1099 VK055_0224 hypothetical protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1100 VK055_5079 hypothetical protein ColabFold –
GO:0003697Binding to single-stranded DNA.
0.827 No Hit 0.0% —
Page of 204 · 5081 total proteins