Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1176 VK055_5164 hypothetical protein ColabFold model – – No map N/A 0.872 No Hit 0.0% —
1177 VK055_4851 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.872 0.449 No Hit 0.0% —
1178 VK055_4795 mepA mepA AlphaFold DB model + ColabFold model
3.4.24.-
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +36 total
No map 0.872 0.248 No Hit 0.0% —
1179 VK055_4276 uxuR transcriptional repressor AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.872 0.187 No Hit 0.0% —
1180 VK055_3846 putative ATP-dependent endonuclease AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
No map 0.872 0.278 Hit 50.0% 5.41e-12
1181 VK055_3096 NUDIX domain protein AlphaFold DB model + ColabFold model
3.6.1.- 3.6.1.22
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000210Catalysis of the reaction: NAD+ + H2O = AMP + NMN. GO:0046872Binding to a metal ion. +811 total
No map 0.872 0.07 Hit 40.7% 1.43e-19
1182 VK055_2302 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain protein AlphaFold DB model + ColabFold model –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
Mapped 1 0.872 0.372 Hit 42.0% 7.22e-09
1183 VK055_2280 proB proB AlphaFold DB model + ColabFold model
2.7.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. +58 total
Chokepoint 1 0.872 0.29 Hit 33.4% 3.33e-32
1184 VK055_2046 oxidoreductase, NAD-binding Rossmann fold family protein AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.872 0.938 Hit 29.7% 3.95e-17
1185 VK055_1897 S-adenosyl-L-homocysteine hydrolase, NAD bindingdomain protein AlphaFold DB model + ColabFold model –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0047545Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. +25 total
No map 0.872 0.548 Hit 41.7% 2.65e-24
1186 VK055_1002 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.872 0.902 No Hit 0.0% —
1187 VK055_0624 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.872 0.92 No Hit 0.0% —
1188 VK055_4787 47 kDa outer membrane protein AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015483Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.871 0.964 No Hit 0.0% —
1189 VK055_4404 adenylylsulfate kinase cysC AlphaFold DB model + ColabFold model
2.7.1.25
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000103The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. GO:0004020Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+. +14 total
Chokepoint 1 0.871 0.934 Hit 52.7% 9.27e-63
1190 VK055_3674 glycogen debranching enzyme GlgX glgX AlphaFold DB model + ColabFold model
3.2.1.196
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004133OBSOLETE. Catalysis of the cleavage of branch points in branched glycogen polymers. GO:0005977The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. +47 total
No map 0.871 0.651 No Hit 0.0% —
1191 VK055_1372 beta-ketoacyl-acyl-carrier-protein synthase II fabF AlphaFold DB model + ColabFold model
2.3.1.179
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +25 total
No map 0.871 0.967 Hit 44.2% 3.04e-112
1192 VK055_0220 3-deoxy-8-phosphooctulonate synthase kdsA AlphaFold DB model + ColabFold model
2.5.1.55
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008676Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Chokepoint 1 0.871 0.305 No Hit 0.0% —
1193 VK055_5101 esterase family protein iroD AlphaFold DB model + ColabFold model –
GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005506Binding to an iron (Fe) ion. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.870 0.557 No Hit 0.0% —
1194 VK055_5081 type IV secretory system Conjugative DNA transfer family protein AlphaFold DB model + ColabFold model – – No map 0.870 0.892 No Hit 0.0% —
1195 VK055_4983 mannitol dehydrogenase Rossmann domain protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008866Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH. +14 total
No map 0.870 0.402 No Hit 0.0% —
1196 VK055_4656 histidine--tRNA ligase hisS AlphaFold DB model + ColabFold model
6.1.1.21
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006427The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. GO:0004821Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). +14 total
Chokepoint 2 0.870 0.645 Hit 25.3% 6.21e-11
1197 VK055_4122 thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0000287Binding to a magnesium (Mg) ion.
No map 0.870 0.918 Hit 32.1% 2.36e-11
1198 VK055_3498 glycosyl transferase 2 family protein AlphaFold DB model + ColabFold model –
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
No map 0.870 0.611 Hit 33.1% 1.29e-10
1199 VK055_0730 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.870 0.328 No Hit 0.0% —
1200 VK055_0015 HD domain protein AlphaFold DB model + ColabFold model – – No map 0.870 0.152 No Hit 0.0% —
Page of 204 · 5081 total proteins