Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1351 VK055_4247 EAL domain protein AlphaFold DB model + ColabFold model –
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.843 0.208 No Hit 0.0% —
1352 VK055_2826 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019213Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
No map 0.843 0.166 No Hit 0.0% —
1353 VK055_1367 putative metallodependent hydrolase AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0004536Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.843 0.333 Hit 35.2% 1.77e-19
1354 VK055_0569 ribonucleoside hydrolase 1 AlphaFold DB model + ColabFold model
3.2.-.-
GO:0045437Catalysis of the reaction: H2O + uridine = ribofuranose + uracil. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0015949The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. +47 total
Mapped 6 0.842 0.662 No Hit 0.0% —
1355 VK055_5056 cobalamin 5'-phosphate synthase cobS2 AlphaFold DB model + ColabFold model
2.7.8.26
GO:0008818Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. GO:0051073Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
Chokepoint 7 0.841 0.489 No Hit 0.0% —
1356 VK055_4110 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.841 No Hit 0.0% —
1357 VK055_3191 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase wecA AlphaFold DB model + ColabFold model
2.7.8.33
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0036380Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +1013 total
Chokepoint 1 0.841 0.433 No Hit 0.0% —
1358 VK055_1111 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.841 0.29 No Hit 0.0% —
1359 VK055_0807 esterase family protein ColabFold model – – No map 0.841 0.891 No Hit 0.0% —
1360 VK055_0481 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.841 0.986 No Hit 0.0% —
1361 VK055_3686 gntT Gluconate Gnt transporter gntT AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.840 0.749 No Hit 0.0% —
1362 VK055_3002 na+/H+ antiporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +710 total
No map 0.840 0.977 Hit 27.9% 5.02e-08
1363 VK055_2293 acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha acoA AlphaFold DB model + ColabFold model –
GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. GO:0004739Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H+ = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2. GO:0006086The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.
Chokepoint 6 0.840 0.579 Hit 36.8% 5.88e-62
1364 VK055_1672 bacterial regulatory, lacI family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.840 0.894 No Hit 0.0% —
1365 VK055_1376 3-oxoacyl-[acyl-carrier-] synthase III family protein fabH AlphaFold DB model + ColabFold model –
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
Mapped 1 0.840 0.217 No Hit 0.0% —
1366 VK055_1375 malonyl CoA-acyl carrier protein transacylase fabD AlphaFold DB model + ColabFold model
2.3.1.39
GO:0004314Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Chokepoint 1 0.840 0.658 Hit 33.2% 1.64e-36
1367 VK055_0632 ppa ppa AlphaFold DB model + ColabFold model
3.6.1.1
GO:0004427Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
No map 0.840 0.689 Hit 34.3% 9.00e-10
1368 VK055_0447 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.840 0.738 No Hit 0.0% —
1369 VK055_0333 thiF family protein AlphaFold DB model + ColabFold model –
GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +47 total
No map 0.840 0.614 No Hit 0.0% —
1370 VK055_0309 periplasmic binding family protein AlphaFold DB model + ColabFold model – – No map 0.840 0.421 No Hit 0.0% —
1371 VK055_5074 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.839 0.541 No Hit 0.0% —
1372 VK055_3889 ftsH HflB hflB AlphaFold DB model + ColabFold model
3.4.24.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +69 total
No map 0.839 0.765 Hit 58.8% 6.65e-46
1373 VK055_3501 putative lipopolysaccharide heptosyltransferase III AlphaFold DB model + ColabFold model
2.4.99.25
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
Mapped 2 0.839 0.725 No Hit 0.0% —
1374 VK055_0327 pyruvate kinase pyk2 AlphaFold DB model + ColabFold model
2.7.1.40
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030955Binding to a potassium ion (K+). GO:0004743Catalysis of the reaction: ADP + H+ + phosphoenolpyruvate = ATP + pyruvate. +58 total
Mapped 4 0.839 0.505 Hit 56.4% 7.25e-09
1375 VK055_4416 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.838 0.337 No Hit 0.0% —
Page of 204 · 5081 total proteins