Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1301 VK055_1667 molybdopterin biosynthesis AlphaFold + ColabFold
2.10.1.1
GO:0032324The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.787 Hit 43.4% 9.54e-32
1302 VK055_0675 glutamine amidotransferase class-I family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.787 No Hit 0.0% —
1303 VK055_2915 fumarate reductase membrane protein frdD AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0045283A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). +25 total
0.786 No Hit 0.0% —
1304 VK055_1928 fecCD transport family protein fepD AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.786 No Hit 0.0% —
1305 VK055_1542 tetraacyldisaccharide 4'-kinase lpxK AlphaFold + ColabFold
2.7.1.130
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0009029Catalysis of the reaction: a lipid A disaccharide + ATP = a lipid IVA + ADP + H+. +25 total
0.786 No Hit 0.0% —
1306 VK055_1507 mce related family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.786 No Hit 0.0% —
1307 VK055_0681 alpha/beta hydrolase fold family protein Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.786 Hit 33.3% 1.66e-11
1308 VK055_0208 putative inner membrane protein AlphaFold + ColabFold – – 0.786 No Hit 0.0% —
1309 VK055_3105 diguanylate cyclase domain protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate.
0.785 No Hit 0.0% —
1310 VK055_2859 NAD(P)H:quinone oxidoreductase ytfG AlphaFold + ColabFold – – 0.785 Hit 27.3% 8.47e-06
1311 VK055_0249 regulator of RpoS hnr AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0097588Cell motility due to movement of bacterial- or archaeal-type flagella. GO:0045862Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. +14 total
0.785 No Hit 0.0% —
1312 VK055_4476 short chain dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.784 Hit 35.5% 5.54e-06
1313 VK055_2016 arylsulfatase atsA AlphaFold + ColabFold –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0046872Binding to a metal ion.
0.784 Hit 41.4% 1.56e-10
1314 VK055_0631 zinc-binding dehydrogenase family protein AlphaFold + ColabFold
1.1.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
0.784 Hit 44.6% 4.93e-07
1315 VK055_4725 ethanolamine utilization, EutH family protein AlphaFold + ColabFold –
GO:0034228Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034229The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. +14 total
0.783 No Hit 0.0% —
1316 VK055_4272 ascG transcriptional repressor AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.783 No Hit 0.0% —
1317 VK055_3564 oxalate/formate antiporter transporter family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.783 Hit 28.7% 8.68e-06
1318 VK055_1768 3-deoxy-7-phosphoheptulonate synthase AlphaFold + ColabFold
2.5.1.54
GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +47 total
0.783 No Hit 0.0% —
1319 VK055_1194 anthranilate synthase component II trpD AlphaFold + ColabFold –
GO:0004048Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.
0.783 No Hit 0.0% —
1320 VK055_0735 hypothetical protein with FAD/NAD(P)-binding domain ydhS AlphaFold + ColabFold – – 0.783 No Hit 0.0% —
1321 VK055_2318 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.782 No Hit 0.0% —
1322 VK055_1858 leucine--tRNA ligase leuS AlphaFold + ColabFold
6.1.1.4
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +58 total
0.782 Hit 73.0% 9.14e-12
1323 VK055_1680 glycosyl hydrolase 1 family protein AlphaFold + ColabFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.782 Hit 29.7% 2.10e-09
1324 VK055_0868 inner membrane protein involved in multiple antibiotic resistance marC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.782 No Hit 0.0% —
1325 VK055_0794 sugar diacid recognition family protein AlphaFold + ColabFold – – 0.782 No Hit 0.0% —
Page of 204 · 5081 total proteins