Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1376 VK055_4250 putative oxidoreductase, NAD(P)-binding protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.838 0.882 Hit 24.2% 8.04e-10
1377 VK055_3258 sensory histidine kinase in two-component regulatory system with CpxR cpxA AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +58 total
No map 0.838 0.839 No Hit 0.0% —
1378 VK055_2778 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase iolD AlphaFold DB model + ColabFold model –
GO:0016823Catalysis of the hydrolysis of any carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +25 total
Chokepoint 1 0.838 0.87 Hit 31.8% 1.05e-07
1379 VK055_1916 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.838 0.699 Hit 41.5% 3.25e-11
1380 VK055_4440 PTS system, lactose/cellobiose IIC component family protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
No map 0.837 0.756 No Hit 0.0% —
1381 VK055_3418 prpF family protein AlphaFold DB model + ColabFold model –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.837 0.814 No Hit 0.0% —
1382 VK055_1581 2Fe-2S iron-sulfur cluster binding domain protein AlphaFold DB model + ColabFold model –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
No map 0.837 0.42 No Hit 0.0% —
1383 VK055_1531 L,D-transpeptidase YcbB AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
Mapped 4 0.837 0.077 No Hit 0.0% —
1384 VK055_0522 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.837 No Hit 0.0% —
1385 VK055_3673 1,4-alpha-glucan branching enzyme glgB AlphaFold DB model + ColabFold model
2.4.1.18
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005978The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. +47 total
No map 0.836 0.384 Hit 25.4% 6.27e-41
1386 VK055_4390 CTP synthase pyrG AlphaFold DB model + ColabFold model
6.3.4.2
GO:0003883Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. +811 total
Mapped 3 0.835 0.654 Hit 62.4% 2.36e-43
1387 VK055_4329 cobalamin biosynthesis protein CbiD cbiD AlphaFold DB model + ColabFold model
2.1.1.195
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0043780Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A. +25 total
No map 0.835 0.142 No Hit 0.0% —
1388 VK055_1796 oxoglutarate dehydrogenase (succinyl-transferring), E1 component sucA AlphaFold DB model + ColabFold model
1.2.4.2
GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. +36 total
Chokepoint 1 0.835 0.729 Hit 47.1% 1.94e-39
1389 VK055_0971 abgT transporter family protein ydaH AlphaFold DB model + ColabFold model –
GO:1902604The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane. GO:0015558Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid.
No map 0.835 0.88 No Hit 0.0% —
1390 VK055_4901 beta-lactamase family protein AlphaFold DB model + ColabFold model – – No map 0.834 0.808 No Hit 0.0% —
1391 VK055_4828 acetate kinase ackA3 AlphaFold DB model + ColabFold model
2.7.2.1
GO:0016774Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006082The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. +710 total
Mapped 2 0.834 0.434 No Hit 0.0% —
1392 VK055_4129 mechanosensitive channel MscS yggB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map N/A 0.834 No Hit 0.0% —
1393 VK055_2836 putative thioredoxin-like protein Experimental + ColabFold model –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.834 0.741 No Hit 0.0% —
1394 VK055_1638 bacteriophage replication gene A family protein ColabFold model –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
No map 0.834 0.781 No Hit 0.0% —
1395 VK055_0991 mannose-6-phosphate isomerase, class I manA AlphaFold DB model + ColabFold model
5.3.1.8
GO:0008270Binding to a zinc ion (Zn). GO:0009298The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +25 total
Chokepoint 3 0.834 0.226 Hit 39.8% 1.47e-29
1396 VK055_4917 mannonate dehydratase uxuA2 AlphaFold DB model + ColabFold model
4.2.1.8
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008927Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. GO:0008198Binding to a ferrous iron ion, Fe(II). +25 total
Chokepoint 1 0.833 0.28 No Hit 0.0% —
1397 VK055_4738 cysP AlphaFold DB model + ColabFold model –
GO:1902358The directed movement of sulfate across a membrane. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. GO:1901681Binding to a sulfur compound. +14 total
No map 0.833 0.302 No Hit 0.0% —
1398 VK055_4301 threonine-phosphate decarboxylase AlphaFold DB model + ColabFold model
4.1.1.81
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +25 total
Mapped 1 0.833 0.535 No Hit 0.0% —
1399 VK055_4277 galR transcriptional repressor GalR transcriptional dual regulator galR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.833 0.379 No Hit 0.0% —
1400 VK055_4188 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.833 0.603 No Hit 0.0% —
Page of 204 · 5081 total proteins