Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1426 VK055_4130 L-lysine exporter family protein lysE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0061459Enables the transfer of L-arginine from one side of a membrane to the other. GO:1903826The directed movement of L-arginine across a membrane. +25 total
No map 0.828 0.912 No Hit 0.0% —
1427 VK055_3801 prokaryotic membrane lipolipid attachment site family protein AlphaFold DB model + ColabFold model – – No map N/A 0.828 No Hit 0.0% —
1428 VK055_3580 endoglucanase AlphaFold DB model + ColabFold model
3.2.1.-
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008810Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. +14 total
No map 0.828 0.469 No Hit 0.0% —
1429 VK055_1170 DNA-binding transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.828 0.268 No Hit 0.0% —
1430 VK055_0224 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.828 No Hit 0.0% —
1431 VK055_0078 pyruvate kinase pyk AlphaFold DB model + ColabFold model
2.7.1.40
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030955Binding to a potassium ion (K+). GO:0004743Catalysis of the reaction: ADP + H+ + phosphoenolpyruvate = ATP + pyruvate. +47 total
Mapped 4 0.828 0.537 Hit 50.0% 5.61e-06
1432 VK055_5013 PAP2 superfamily protein AlphaFold DB model + ColabFold model – – No map 0.826 0.897 No Hit 0.0% —
1433 VK055_4400 M42 glutamyl aminopeptidase family protein AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008235Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. +14 total
No map 0.826 0.369 No Hit 0.0% —
1434 VK055_4123 porin D oprD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.826 0.922 No Hit 0.0% —
1435 VK055_2081 SPFH domain / Band 7 family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map N/A 0.826 Hit 51.0% 5.95e-07
1436 VK055_1301 3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein Experimental + ColabFold model –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
No map 0.826 0.858 No Hit 0.0% —
1437 VK055_0030 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +14 total
No map 0.826 0.8 No Hit 0.0% —
1438 VK055_2681 putative regulator AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
No map 0.825 0.729 Hit 30.4% 2.27e-15
1439 VK055_2232 extensin-like family protein AlphaFold DB model + ColabFold model – – No map 0.825 0.665 No Hit 0.0% —
1440 VK055_2104 acrR transcriptional regulator AcrR transcriptional repressor acrR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
No map 0.825 0.869 No Hit 0.0% —
1441 VK055_1728 dethiobiotin synthase bioD AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
Chokepoint 3 0.825 0.758 No Hit 0.0% —
1442 VK055_1600 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.825 0.964 No Hit 0.0% —
1443 VK055_1536 ubiE/COQ5 methyltransferase family protein AlphaFold DB model + ColabFold model
2.1.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0097697Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine. The methylation occurs on the modified base. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
No map 0.825 0.933 No Hit 0.0% —
1444 VK055_4591 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.824 0.933 No Hit 0.0% —
1445 VK055_2939 regulator yjdC AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.824 0.864 No Hit 0.0% —
1446 VK055_1146 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.824 0.912 No Hit 0.0% —
1447 VK055_0511 electron transport complex, RnfABCDGE type, D subunit AlphaFold DB model + ColabFold model
7.-.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.824 0.971 No Hit 0.0% —
1448 VK055_5063 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.823 0.411 No Hit 0.0% —
1449 VK055_2385 protein-P-II uridylyltransferase glnD AlphaFold DB model + ColabFold model –
GO:0008773Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +36 total
No map 0.823 0.586 No Hit 0.0% —
1450 VK055_1904 inositol monophosphatase family protein AlphaFold DB model + ColabFold model
3.1.3.25
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. GO:0006020The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +25 total
No map 0.823 0.242 Hit 35.0% 2.64e-06
Page of 204 · 5081 total proteins