Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4645 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
126 VK055_4575 diguanylate cyclase domain protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
0.986 No Hit 0.0% —
127 VK055_2624 sulfatase family protein AlphaFold + ColabFold –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
0.986 No Hit 0.0% —
128 VK055_1007 putative aldehyde dehydrogenase AlphaFold + ColabFold –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +58 total
0.986 Hit 42.9% 5.20e-06
129 VK055_0481 major Facilitator Superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.986 No Hit 0.0% —
130 VK055_0339 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase mhpA AlphaFold + ColabFold
1.14.13.127
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0019622The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. GO:0008688Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. +14 total
0.986 Hit 23.2% 6.84e-10
131 VK055_4958 binding-protein-dependent transport system innermembrane component family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.985 No Hit 0.0% —
132 VK055_4769 mntH manganese ion transporter mntH AlphaFold + ColabFold –
GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +69 total
0.985 Hit 46.4% 4.91e-17
133 VK055_4192 ureF family protein AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.985 No Hit 0.0% —
134 VK055_4116 major Facilitator Superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.985 Hit 22.6% 3.27e-08
135 VK055_3950 inner membrane protein ygjV AlphaFold + ColabFold – – 0.985 No Hit 0.0% —
136 VK055_3808 ribosomal protein L11 methyltransferase prmA AlphaFold + ColabFold
2.1.1.-
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.985 No Hit 0.0% —
137 VK055_3330 ATP synthase F0, A subunit atpB AlphaFold + ColabFold –
GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0015078Enables the transfer of a proton from one side of a membrane to the other. GO:0045263OBSOLETE. All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. +47 total
0.985 No Hit 0.0% —
138 VK055_3255 yiiP fieF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +1013 total
0.985 Hit 23.5% 2.86e-09
139 VK055_3033 qor qor AlphaFold + ColabFold
1.6.5.5
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.985 Hit 45.9% 7.48e-08
140 VK055_1812 dipeptide permease D dtpD AlphaFold + ColabFold –
GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +811 total
0.985 Hit 32.7% 5.60e-23
141 VK055_1043 primary amine oxidase maoA AlphaFold + ColabFold
1.4.3.-
GO:0005507Binding to a copper (Cu) ion. GO:0008131Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +36 total
0.985 Hit 28.1% 3.19e-32
142 VK055_0898 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.985 No Hit 0.0% —
143 VK055_4462 glycosyl hydrolase 1 family protein AlphaFold + ColabFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.984 Hit 39.6% 1.75e-14
144 VK055_4013 bacterial SH3 domain protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.984 No Hit 0.0% —
145 VK055_3875 mlaC yrbC AlphaFold + ColabFold – – 0.984 No Hit 0.0% —
146 VK055_3735 alpha/beta hydrolase fold family protein AlphaFold + ColabFold –
GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0034338Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.
0.984 Hit 32.4% 9.52e-15
147 VK055_3709 shikimate kinase family protein AlphaFold + ColabFold
2.7.1.71
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.984 Hit 29.5% 1.81e-07
148 VK055_2341 methyltransferase domain protein AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.984 Hit 31.1% 1.61e-07
149 VK055_2073 ftsX-like permease family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.984 No Hit 0.0% —
150 VK055_1978 efflux pump membrane transporter BepE bepE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.984 No Hit 0.0% —
Page of 186 · 4645 total proteins