Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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161 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
126 VK055_5144 protein mtfA mtfA2 Experimental + ColabFold –
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.361 No Hit 0.0% —
127 VK055_5033 glycosyl transferase 8 family protein Experimental + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0046872Binding to a metal ion.
0.358 Hit 22.6% 1.67e-07
128 VK055_0985 response regulator Experimental + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.347 No Hit 0.0% —
129 VK055_4343 cobU cobU Experimental + ColabFold
2.7.1.156 2.7.7.62
GO:0043752Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +36 total
0.345 No Hit 0.0% —
130 VK055_0895 class II Aldolase and Adducin N-terminal domain protein Experimental + ColabFold
4.1.1.104
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0046872Binding to a metal ion. +14 total
0.345 Hit 28.3% 5.08e-06
131 VK055_2987 sel1 repeat family protein Experimental + ColabFold –
GO:0005515Binding to a protein.
0.343 No Hit 0.0% —
132 VK055_1259 glycosyl hydrolases 18 family protein Experimental + ColabFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008061Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
0.339 Hit 36.8% 5.07e-07
133 VK055_1057 outer membrane protein C ompC2 Experimental + ColabFold –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
0.339 No Hit 0.0% —
134 VK055_3287 ribbon-helix-helix, copG family protein Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
0.333 No Hit 0.0% —
135 VK055_0857 bacterial regulatory helix-turn-helix, lysR family protein Experimental + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.331 No Hit 0.0% —
136 VK055_1759 molybdate ABC transporter, periplasmic molybdate-binding protein modA Experimental + ColabFold –
GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. +25 total
0.329 No Hit 0.0% —
137 VK055_3153 sugar phosphatase Experimental + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.325 No Hit 0.0% —
138 VK055_3300 ribosome biogenesis GTP-binding protein YsxC ysxC Experimental + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate.
0.319 Hit 35.1% 5.93e-19
139 VK055_4683 ppx ppx Experimental + ColabFold
3.6.1.11
GO:0006793The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus. GO:0004309Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.317 No Hit 0.0% —
140 VK055_4689 uracil phosphoribosyltransferase upp Experimental + ColabFold –
GO:0006223Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. GO:0004845Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
0.314 Hit 28.7% 2.62e-09
141 VK055_3890 dihydropteroate synthase folP Experimental + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0004156Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. GO:0042558The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. +14 total
0.307 No Hit 0.0% —
142 VK055_0058 glycosyl Hydrolase Family 88 family protein Experimental + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.302 No Hit 0.0% —
143 VK055_0821 hydroxyisourate hydrolase uraH Experimental + ColabFold –
GO:0006144The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0033971Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+.
0.295 No Hit 0.0% —
144 VK055_2631 putative PTS permease Experimental + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.29 No Hit 0.0% —
145 VK055_3869 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase yrbI Experimental + ColabFold
3.1.3.45
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0019143Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872Binding to a metal ion. +25 total
0.287 Hit 32.3% 1.02e-18
146 VK055_3978 hypothetical protein Experimental + ColabFold –
GO:0046872Binding to a metal ion.
0.283 No Hit 0.0% —
147 VK055_3931 hypothetical protein Experimental + ColabFold – – 0.271 No Hit 0.0% —
148 VK055_2684 ribosyldihydronicotinamide dehydrogenase (quinone) nqo2 Experimental + ColabFold – – 0.26 Hit 51.9% 1.59e-10
149 VK055_4029 hypothetical protein Experimental + ColabFold – – 0.251 No Hit 0.0% —
150 VK055_4525 NADH-azoreductase, FMN-dependent Experimental + ColabFold –
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
0.25 No Hit 0.0% —
Page of 7 · 161 total proteins