Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1651 VK055_1010 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.782 0.95 No Hit 0.0% —
1652 VK055_0323 cysteine desulfurase sufS AlphaFold DB model + ColabFold model –
GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +14 total
Chokepoint 22 0.782 0.513 Hit 32.1% 5.17e-07
1653 VK055_4421 hokE hokE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.781 No Hit 0.0% —
1654 VK055_3851 N-acetylmannosamine-6-phosphate 2-epimerase yhcJ AlphaFold DB model + ColabFold model –
GO:0047465Catalysis of the reaction: an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate. GO:0006051The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.
Mapped 2 0.781 0.375 No Hit 0.0% —
1655 VK055_3669 gntK gntK AlphaFold DB model + ColabFold model
2.7.1.12
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.781 0.173 Hit 54.3% 1.82e-08
1656 VK055_1801 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.781 No Hit 0.0% —
1657 VK055_1515 nitrate transport protein ssuA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.781 0.671 No Hit 0.0% —
1658 VK055_1032 3-oxoadipyl-CoA thiolase pcaF2 AlphaFold DB model + ColabFold model
2.3.1.174
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +14 total
Mapped 2 0.781 0.801 Hit 47.5% 6.60e-60
1659 VK055_3857 mannonate dehydratase uxuA AlphaFold DB model + ColabFold model
4.2.1.8
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008927Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. GO:0008198Binding to a ferrous iron ion, Fe(II). +25 total
Chokepoint 1 0.780 0.664 No Hit 0.0% —
1660 VK055_3697 envZ envZ AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +25 total
No map 0.780 0.902 No Hit 0.0% —
1661 VK055_1263 glyceraldehyde-3-phosphate dehydrogenase, type I gap2 AlphaFold DB model + ColabFold model
1.2.1.-
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
No map 0.780 0.502 Hit 69.7% 7.91e-128
1662 VK055_4051 glycosyl hydrolases 43 family protein AlphaFold DB model + ColabFold model –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.779 0.704 No Hit 0.0% —
1663 VK055_3073 shikimate / quinate 5-dehydrogenase family protein AlphaFold DB model + ColabFold model
1.1.1.25
GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +25 total
No map 0.779 0.435 No Hit 0.0% —
1664 VK055_3224 fabR transcriptional repressor FabR transcriptional dual regulator fabR AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.778 0.938 No Hit 0.0% —
1665 VK055_2506 thiamin/thiamine pyrophosphate ABC transporter, thiamin/thiamine pyrophospate-binding protein thiB AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015888The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
No map 0.778 0.928 No Hit 0.0% —
1666 VK055_2368 DNA polymerase III, &alpha subunit AlphaFold DB model + ColabFold model
2.7.7.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003676Binding to a nucleic acid. +36 total
No map 0.778 0.598 No Hit 0.0% —
1667 VK055_2036 sucrose-6-phosphate hydrolase scrB AlphaFold DB model + ColabFold model –
GO:0004564Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +14 total
Chokepoint 8 0.778 0.881 No Hit 0.0% —
1668 VK055_1665 nickel import ATP-binding protein NikE nikE2 AlphaFold DB model + ColabFold model
7.4.2.10
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
No map 0.778 0.997 Hit 39.4% 1.49e-06
1669 VK055_4511 ribonucleoside-diphosphate reductase, alpha subunit AlphaFold DB model + ColabFold model
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
Mapped 8 0.777 0.238 Hit 33.0% 5.47e-10
1670 VK055_2520 histidine kinase-, DNA gyrase B-, and HSP90-likeATPase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +14 total
No map 0.777 0.933 No Hit 0.0% —
1671 VK055_2493 2-isopropylmalate synthase leuA AlphaFold DB model + ColabFold model
2.3.3.13
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0003852Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +58 total
Mapped 1 0.777 0.206 Hit 25.0% 5.45e-07
1672 VK055_0145 transporter associated domain protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +811 total
No map 0.777 0.654 No Hit 0.0% —
1673 VK055_3784 ribosomal RNA small subunit methyltransferase B sun AlphaFold DB model + ColabFold model
2.1.1.176
GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. +69 total
Mapped 1 0.776 0.079 Hit 34.5% 2.49e-23
1674 VK055_0957 fumarase A fumA2 AlphaFold DB model + ColabFold model
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006091The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. +58 total
Mapped 1 0.776 0.481 No Hit 0.0% —
1675 VK055_0637 hypothetical protein ColabFold model – – No map N/A 0.776 No Hit 0.0% —
Page of 204 · 5081 total proteins