Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1651 VK055_0955 putative transcriptional regulator AlphaFold + ColabFold – – 0.723 No Hit 0.0% —
1652 VK055_0765 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.723 Hit 37.4% 9.64e-20
1653 VK055_0066 isochorismatase family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.723 No Hit 0.0% —
1654 VK055_4285 hypothetical protein AlphaFold + ColabFold – – 0.722 No Hit 0.0% —
1655 VK055_3871 yrbG CaCA transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
0.722 Hit 47.4% 2.81e-07
1656 VK055_3721 hypothetical protein ColabFold – – 0.722 No Hit 0.0% —
1657 VK055_3598 putative transcriptional regulator LYSR-type AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.722 No Hit 0.0% —
1658 VK055_3065 hypothetical protein AlphaFold + ColabFold – – 0.722 No Hit 0.0% —
1659 VK055_2396 glutamate-1-semialdehyde-2,1-aminomutase hemL AlphaFold + ColabFold
5.4.3.8
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042286Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +47 total
0.722 Hit 29.2% 1.73e-25
1660 VK055_2313 csiR transcriptional repressor ygaE AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.722 No Hit 0.0% —
1661 VK055_4652 ndk ndk AlphaFold + ColabFold
2.7.4.6
GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0006228The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. +47 total
0.721 Hit 51.4% 1.87e-18
1662 VK055_2486 S-adenosyl-methyltransferase MraW mraW AlphaFold + ColabFold
2.1.1.199
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071424Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. +14 total
0.721 Hit 40.7% 1.40e-23
1663 VK055_2208 antibiotic biosynthesis monooxygenase family protein AlphaFold + ColabFold – – 0.721 No Hit 0.0% —
1664 VK055_0897 H+ symporter family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
0.721 No Hit 0.0% —
1665 VK055_0805 hypothetical protein AlphaFold + ColabFold – – 0.721 No Hit 0.0% —
1666 VK055_0746 periplasmic binding and sugar binding domain of LacI family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.721 No Hit 0.0% —
1667 VK055_0329 hypothetical protein AlphaFold + ColabFold
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O.
0.721 No Hit 0.0% —
1668 VK055_4571 ribosomal protein L19 rplS AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
0.72 No Hit 0.0% —
1669 VK055_4034 qseB transcriptional activator AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +47 total
0.72 No Hit 0.0% —
1670 VK055_3059 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.72 No Hit 0.0% —
1671 VK055_3012 bacterial extracellular solute-binding family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.72 No Hit 0.0% —
1672 VK055_2629 PTS system sorbose-specific iic component familyprotein AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.72 No Hit 0.0% —
1673 VK055_2441 FKBP-type peptidyl-prolyl cis-trans isomerase family protein AlphaFold + ColabFold
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0000775The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. +36 total
0.72 No Hit 0.0% —
1674 VK055_2401 hypothetical protein AlphaFold + ColabFold – – 0.72 No Hit 0.0% —
1675 VK055_0939 malonate decarboxylase, alpha subunit mdcA AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.72 No Hit 0.0% —
Page of 204 · 5081 total proteins