Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1701 VK055_1006 glyceraldehyde-3-phosphate dehydrogenase, type I gap AlphaFold DB model + ColabFold model
1.2.1.-
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +25 total
No map 0.769 0.381 Hit 46.5% 1.05e-73
1702 VK055_2877 ulaA ulaA AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.768 0.853 No Hit 0.0% —
1703 VK055_1460 putative DNA-binding transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
No map 0.768 0.546 No Hit 0.0% —
1704 VK055_3738 proton antiporter-2 family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +69 total
No map 0.767 0.763 Hit 35.9% 1.95e-09
1705 VK055_4863 L-rhamnonate dehydratase rhmD AlphaFold DB model + ColabFold model
4.2.1.90
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0050032Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. GO:0000287Binding to a magnesium (Mg) ion. +14 total
Chokepoint 1 0.766 0.695 No Hit 0.0% —
1706 VK055_3170 adenylate cyclase, class-I family protein AlphaFold DB model + ColabFold model
4.6.1.1
GO:0006171The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). GO:0004016Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.766 0.887 No Hit 0.0% —
1707 VK055_2479 cell division protein FtsW ftsW AlphaFold DB model + ColabFold model
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +710 total
No map 0.766 0.835 No Hit 0.0% —
1708 VK055_1320 NUDIX domain protein AlphaFold DB model + ColabFold model
3.6.1.-
GO:0004787Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0017110Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. +14 total
No map 0.766 0.086 Hit 28.4% 3.26e-06
1709 VK055_0059 arginine--tRNA ligase argS Experimental + AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +47 total
Chokepoint 2 0.766 0.198 Hit 63.3% 3.06e-18
1710 VK055_4793 N5-glutamine methyltransferase, ribosomal protein L3-specific prmB AlphaFold DB model + ColabFold model
2.1.1.298
GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. GO:0003676Binding to a nucleic acid. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. +710 total
No map 0.765 0.957 Hit 29.0% 2.45e-14
1711 VK055_3702 intracellular growth attenuator IgaA family protein Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.765 0.876 No Hit 0.0% —
1712 VK055_2622 chromosome replication; initiation and chain elongation dnaC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +36 total
No map 0.765 0.162 No Hit 0.0% —
1713 VK055_2596 putative DNase AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion.
No map 0.765 0.28 Hit 34.6% 6.47e-14
1714 VK055_0209 hypothetical protein ColabFold model – – No map N/A 0.765 No Hit 0.0% —
1715 VK055_4689 uracil phosphoribosyltransferase upp Experimental + ColabFold model –
GO:0006223Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. GO:0004845Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
Chokepoint 1 0.764 0.314 Hit 28.7% 2.62e-09
1716 VK055_3167 diaminopimelate epimerase dapF AlphaFold DB model + ColabFold model
5.1.1.7
GO:0008837Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Chokepoint 1 0.764 0.203 No Hit 0.0% —
1717 VK055_0066 isochorismatase family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.764 0.723 No Hit 0.0% —
1718 VK055_3368 2-oxo-3-deoxygalactonate 6-phosphate aldolase dgoA AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Chokepoint 1 0.763 0.411 No Hit 0.0% —
1719 VK055_3251 ATP-dependent protease HslVU, ATPase subunit hslU AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. +36 total
No map 0.763 0.618 Hit 29.4% 1.82e-17
1720 VK055_2572 thrA thrA AlphaFold DB model + ColabFold model –
GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +1013 total
Mapped 1 0.763 0.729 No Hit 0.0% —
1721 VK055_1584 ltaA AlphaFold DB model + ColabFold model –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Mapped 1 0.763 0.453 No Hit 0.0% —
1722 VK055_1549 phosphoserine transaminase serC Experimental + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004648Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine.
Mapped 2 0.763 0.699 Hit 47.8% 1.14e-118
1723 VK055_4635 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.762 0.707 No Hit 0.0% —
1724 VK055_2746 KAP family P-loop domain protein AlphaFold DB model + ColabFold model – – No map 0.762 0.67 No Hit 0.0% —
1725 VK055_1150 phage shock protein A pspA AlphaFold DB model + ColabFold model – – No map N/A 0.762 No Hit 0.0% —
Page of 204 · 5081 total proteins