Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 VK055_1797 succinate dehydrogenase iron-sulfur protein sdhB AlphaFold + ColabFold
1.3.5.1
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +710 total
0.437 Hit 68.9% 1.16e-42
152 VK055_0501 pyridoxamine 5'-phosphate oxidase pdxH AlphaFold + ColabFold
1.4.3.5
GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +14 total
0.553 Hit 47.4% 2.38e-42
153 VK055_5008 uridine kinase udk AlphaFold + ColabFold
2.7.1.48
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.556 Hit 37.6% 2.91e-42
154 VK055_4841 NADH oxidoreductase (quinone), F subunit nuoF AlphaFold + ColabFold
7.1.1.-
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +36 total
0.769 Hit 54.1% 3.45e-42
155 VK055_1811 deoxyribodipyrimidine photolyase AlphaFold + ColabFold
4.1.99.3
GO:0003904Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +25 total
0.867 Hit 28.2% 5.15e-42
156 VK055_3100 thiazole biosynthesis adenylyltransferase ThiF thiF AlphaFold + ColabFold –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.159 Hit 41.0% 5.49e-42
157 VK055_3970 dihydroxyacetone kinase dhaK2 AlphaFold + ColabFold
2.7.1.29
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. +25 total
0.994 Hit 50.3% 6.68e-42
158 VK055_4625 glyA glyA AlphaFold + ColabFold –
GO:0019264OBSOLETE. The chemical reactions and pathways resulting in the formation of glycine from L-serine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. +25 total
0.418 Hit 57.0% 7.34e-42
159 VK055_3880 octaprenyl-diphosphate synthase ispB AlphaFold + ColabFold –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
0.903 Hit 31.0% 8.67e-42
160 VK055_3449 &alpha-xylosidase AlphaFold + ColabFold
3.2.1.177
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
0.212 Hit 29.8% 9.09e-42
161 VK055_1719 molybdenum cofactor biosynthesis protein C moaC AlphaFold + ColabFold
4.6.1.17
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0061799Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
0.472 Hit 47.7% 1.55e-41
162 VK055_2849 methionine sulfoxide reductase A msrA AlphaFold + ColabFold
1.8.4.11
GO:0008113Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033744Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol. +14 total
0.021 Hit 70.7% 3.01e-41
163 VK055_3673 1,4-alpha-glucan branching enzyme glgB AlphaFold + ColabFold
2.4.1.18
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005978The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. +47 total
0.384 Hit 25.4% 6.27e-41
164 VK055_1889 2,3-diketo-5-methylthio-1-phosphopentane phosphatase mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 50.0% 8.59e-41
165 VK055_0446 pfkB carbohydrate kinase family protein AlphaFold + ColabFold
2.7.1.15
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. GO:0004747Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. +47 total
0.15 Hit 35.4% 1.14e-40
166 VK055_1984 metallo-beta-lactamase superfamily protein romA AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0070290Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
0.408 Hit 31.8% 1.27e-40
167 VK055_0791 SMP-30/Gluconolaconase/LRE-like region family protein AlphaFold + ColabFold –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
0.546 Hit 32.7% 4.01e-40
168 VK055_2197 queuine tRNA-ribosyltransferase tgt AlphaFold + ColabFold
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0008479Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. +47 total
0.64 Hit 48.9% 5.60e-40
169 VK055_1874 carbon-nitrogen hydrolase family protein AlphaFold + ColabFold –
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.327 Hit 35.5% 7.99e-40
170 VK055_0687 diaminobutyrate--2-oxoglutarate aminotransferase dat AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +14 total
0.578 Hit 29.7% 1.38e-39
171 VK055_1198 hypothetical protein AlphaFold + ColabFold –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.477 Hit 44.1% 1.66e-39
172 VK055_3713 ribulose-phosphate 3-epimerase rpe AlphaFold + ColabFold
5.1.3.1
GO:0016857Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. GO:0004750Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.267 Hit 39.5% 1.84e-39
173 VK055_1796 oxoglutarate dehydrogenase (succinyl-transferring), E1 component sucA AlphaFold + ColabFold
1.2.4.2
GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. +36 total
0.729 Hit 47.1% 1.94e-39
174 VK055_5058 S-adenosyl-L-homocysteine hydrolase, NAD bindingdomain protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
0.648 Hit 32.7% 2.20e-39
175 VK055_1100 type VI secretion ATPase, ClpV1 family clpV AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.394 Hit 35.3% 4.68e-39
Page of 204 · 5081 total proteins